Basic Information
ID: ALA5260446
Type: Binding
Description: Inhibition of NLRP3 inflammasome activation in PMA-differentiated human THP-1 cells assessed as reduction in IL-1beta secretion preincubated for 20 hrs followed by nigericin addition and measured after 3 hrs by HTRF assay
Organism: Homo sapiens
Cell type: THP-1
Activity Charts
Bioactivity
Activity Types for Assay ALA5260446
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 331.40 | 2.51 | 2.51 |
| 333.82 | 2.71 | 2.71 |
| 329.40 | 2.07 | 2.07 |
| 367.38 | 3.08 | 3.08 |
| 347.39 | 2.21 | 2.21 |
| 339.44 | 2.94 | 2.94 |