Basic Information
ID: ALA5260458
Type: Binding
Description: Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 10 mins by HTRF assay
Format: BAO_0000357
Organism: Homo sapiens
Target: Epidermal growth factor receptor erbB1(ALA203)
Document: ALA5257147
Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) using TK-substrate preincubated with enzyme for 30 mins followed by substrate and ATP addition for 10 mins by HTRF assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5260458
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 393.44 | 3.41 | 3.41 |
| 499.62 | 4.51 | 4.51 |
| 584.11 | 5.09 | 5.09 |
| 585.71 | 5.08 | 5.08 |
| 562.67 | 6.13 | 6.13 |
| 514.63 | 4.70 | 4.70 |
| 542.68 | 5.48 | 5.48 |
| 548.65 | 5.36 | 5.36 |
| 566.64 | 5.50 | 5.50 |
| 514.63 | 4.88 | 4.88 |
| 570.69 | 5.61 | 5.61 |
| 528.66 | 5.47 | 5.47 |