Basic Information
ID: ALA5261223
Type: Binding
Description: Inhibition of human N-terminal 6His-tagged IDH1 R132H mutant expressed in Escherichia coli Rosetta2 (DE3) assessed as effect on intracellular 2-HG level incubated for 60 mins in presence of alpha-ketoglutarate and NADPH by LC/MS/MS analysis
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA5261223
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 326.40 | 3.63 | 3.63 |
| 326.40 | 3.63 | 3.63 |
| 326.40 | 3.63 | 3.63 |
| 326.40 | 3.63 | 3.63 |
| 376.46 | 4.78 | 4.78 |
| 356.43 | 3.64 | 3.64 |
| 376.46 | 4.78 | 4.78 |
| 356.43 | 3.64 | 3.64 |
| 344.39 | 3.77 | 3.77 |
| 356.43 | 3.64 | 3.64 |
| 360.85 | 4.28 | 4.28 |
| 332.45 | 3.84 | 3.84 |
| 418.50 | 5.42 | 5.42 |
| 344.39 | 3.77 | 3.77 |
| 362.82 | 3.07 | 3.07 |
| 436.49 | 4.54 | 4.54 |
| 438.46 | 4.35 | 4.35 |
| 344.39 | 3.77 | 3.77 |
| 402.50 | 5.30 | 5.30 |
| 326.40 | 3.63 | 3.63 |
| 395.29 | 4.94 | 4.94 |
| 351.41 | 3.50 | 3.50 |
| 404.47 | 4.09 | 4.09 |
| 386.45 | 3.65 | 3.65 |
| 360.85 | 4.28 | 4.28 |
| 326.40 | 3.63 | 3.63 |