Basic Information
ID: ALA5265491
Type: Binding
Description: Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux preincubated for 5 mins followed by ethyl 4-methoxy-2-phenylthiazole-5-carboxylate addition and measured for 3 mins by FLIPR assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: HEK293
Target: Transient receptor potential cation channel subfamily M member 8(ALA1075319)
Document: ALA5260854
Inhibition of human TRPM8 expressed in HEK293 cells assessed as reduction in ethyl 4-methoxy-2-phenylthiazole-5-carboxylate induced Ca2+ efflux preincubated for 5 mins followed by ethyl 4-methoxy-2-phenylthiazole-5-carboxylate addition and measured for 3 mins by FLIPR assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA5265491
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 249.29 | 2.69 | 2.69 |
| 283.74 | 3.35 | 3.35 |
| 265.31 | 3.64 | 3.64 |
| 322.36 | 3.21 | 3.21 |
| 277.28 | 3.01 | 3.01 |
| 277.28 | 3.01 | 3.01 |
| 263.32 | 3.00 | 3.00 |
| 342.21 | 3.50 | 3.50 |
| 289.32 | 1.89 | 1.89 |
| 279.34 | 3.88 | 3.88 |
| 287.35 | 2.50 | 2.50 |
| 251.28 | 3.25 | 3.25 |
| 289.32 | 1.89 | 1.89 |
| 291.31 | 2.33 | 2.33 |
| 287.35 | 2.50 | 2.50 |
| 267.28 | 2.83 | 2.83 |
| 308.33 | 2.82 | 2.82 |
| 267.28 | 2.83 | 2.83 |
| 283.74 | 3.35 | 3.35 |
| 302.36 | 2.23 | 2.23 |
| 275.30 | 0.98 | 0.98 |
| 307.77 | 2.84 | 2.84 |
| 294.31 | 2.08 | 2.08 |
| 221.24 | 2.21 | 2.21 |
| 248.31 | 2.27 | 2.27 |
| 263.32 | 3.00 | 3.00 |
| 248.31 | 2.57 | 2.57 |
| 277.28 | 1.85 | 1.85 |
| 263.32 | 2.62 | 2.62 |
| 308.33 | 2.47 | 2.47 |
| 233.29 | 2.99 | 2.99 |
| 306.34 | 2.39 | 2.39 |
| 291.31 | 2.33 | 2.33 |
| 296.32 | 2.68 | 2.68 |
| 303.35 | 2.20 | 2.20 |
| 265.31 | 3.49 | 3.49 |
| 260.26 | 3.38 | 3.38 |
| 344.31 | 3.49 | 3.49 |
| 282.30 | 2.29 | 2.29 |
| 350.40 | 3.33 | 3.33 |
| 224.72 | 3.45 | 3.45 |
| 288.34 | 1.77 | 1.77 |
| 274.31 | 1.58 | 1.58 |
| 262.33 | 2.61 | 2.61 |
| 308.33 | 2.13 | 2.13 |
| 237.25 | 2.86 | 2.86 |
| 235.26 | 2.30 | 2.30 |
| 294.31 | 2.43 | 2.43 |
| 267.67 | 2.88 | 2.88 |
| 292.32 | 2.00 | 2.00 |
| 316.39 | 2.26 | 2.26 |
| 296.33 | 3.66 | 3.66 |
| 263.26 | 1.83 | 1.83 |
| 235.26 | 2.30 | 2.30 |
| 294.33 | 2.24 | 2.24 |
| 263.32 | 2.48 | 2.48 |
| 303.35 | 2.20 | 2.20 |
| 291.31 | 2.33 | 2.33 |
| 289.32 | 1.89 | 1.89 |
| 280.31 | 1.85 | 1.85 |