Basic Information
ID: ALA5291797
Type: Functional
Description: Antagonist activity at human GABRA1 in an in vitro cell-based assay measured by fluorescent imaging plate reader
Activity Charts
Bioactivity
Activity Types for Assay ALA5291797
AC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 361.37 | 1.54 | 1.54 |
| 135.21 | 1.58 | 1.58 |
| 303.29 | 1.77 | 1.77 |
| 441.55 | 4.37 | 4.37 |
| 252.27 | 1.77 | 1.77 |
| 804.03 | 4.64 | 4.64 |
| 407.51 | 4.95 | 4.95 |
| 416.36 | 1.89 | 1.89 |
| 401.44 | 2.37 | 2.37 |
| 581.67 | 1.99 | 1.99 |
| 326.83 | 3.72 | 3.72 |
| 393.47 | 4.51 | 4.51 |
| 375.87 | 4.43 | 4.43 |
| 278.44 | 5.66 | 5.66 |
| 395.48 | 3.22 | 3.22 |
| 243.39 | 4.33 | 4.33 |
| 266.39 | 3.53 | 3.53 |
| 232.28 | 1.35 | 1.35 |
| 654.61 | 3.19 | 3.19 |
| 410.49 | 3.59 | 3.59 |
| 305.50 | 3.20 | 3.20 |
| 264.32 | 2.47 | 2.47 |
| 333.36 | 1.61 | 1.61 |
| 178.27 | 3.64 | 3.64 |
| 278.36 | 3.95 | 3.95 |
| 314.50 | 4.27 | 4.27 |
| 733.94 | 1.79 | 1.79 |
| 426.56 | 4.13 | 4.13 |
| 426.49 | 4.83 | 4.83 |
| 399.44 | 2.87 | 2.87 |
| 393.44 | 3.41 | 3.41 |
| 365.79 | 2.36 | 2.36 |
| 463.80 | 5.94 | 5.94 |
| 238.33 | 2.85 | 2.85 |
| 151.16 | 1.35 | 1.35 |
| 395.46 | 2.55 | 2.55 |
| 260.38 | 2.85 | 2.85 |
| 131.13 | -0.62 | -0.62 |
| 382.54 | 3.95 | 3.95 |
| 146.24 | -1.92 | -1.92 |
| 396.45 | 0.59 | 0.59 |
| 354.47 | 1.70 | 1.70 |
| 383.47 | -0.31 | -0.31 |
| 295.41 | 1.32 | 1.32 |
| 341.45 | 3.24 | 3.24 |
| 381.91 | 4.30 | 4.30 |
| 277.41 | 4.21 | 4.21 |
| 189.22 | 0.16 | 0.16 |
| 159.23 | 1.75 | 1.75 |
| 183.21 | 0.35 | 0.35 |
| 367.81 | 0.62 | 0.62 |
| 355.87 | 5.18 | 5.18 |
| 218.10 | 0.86 | 0.86 |
| 213.66 | 1.86 | 1.86 |
| 475.36 | 4.43 | 4.43 |
| 312.44 | 3.44 | 3.44 |
| 331.87 | 4.88 | 4.88 |
| 211.18 | 0.02 | 0.02 |
| 234.20 | 2.78 | 2.78 |
| 347.22 | -1.86 | -1.86 |
| 303.83 | 4.19 | 4.19 |
| 260.38 | 2.85 | 2.85 |
| 160.22 | 1.23 | 1.23 |
| 299.35 | -0.18 | -0.18 |
| 199.16 | -1.10 | -1.10 |
| 327.47 | 3.37 | 3.37 |
| 612.63 | 3.63 | 3.63 |
| 378.32 | 4.45 | 4.45 |
| 142.16 | -0.91 | -0.91 |
| 158.16 | -1.94 | -1.94 |
| 194.15 | -2.08 | -2.08 |
| 319.25 | 3.93 | 3.93 |
| 246.31 | -0.28 | -0.28 |
| 621.93 | 4.63 | 4.63 |
| 263.79 | 3.96 | 3.96 |
| 435.44 | -1.17 | -1.17 |
| 546.59 | -1.30 | -1.30 |
| 289.55 | 5.14 | 5.14 |
| 295.45 | 4.37 | 4.37 |
| 381.45 | 3.77 | 3.77 |
| 470.61 | 6.33 | 6.33 |
| 218.26 | 1.47 | 1.47 |
| 246.10 | 1.55 | 1.55 |
| 290.79 | 3.40 | 3.40 |
| 588.56 | 1.34 | 1.34 |
| 363.41 | 1.70 | 1.70 |
| 277.19 | 3.00 | 3.00 |
| 471.52 | 2.99 | 2.99 |
| 480.65 | 4.94 | 4.94 |
| 269.35 | 1.91 | 1.91 |
| 214.27 | 2.19 | 2.19 |
| 404.34 | 5.50 | 5.50 |
| 554.59 | -1.20 | -1.20 |
| 308.31 | 2.76 | 2.76 |
| 171.24 | 1.37 | 1.37 |
| 305.42 | 3.79 | 3.79 |
| 147.20 | -0.21 | -0.21 |
| 352.74 | 4.09 | 4.09 |
| 270.21 | 3.00 | 3.00 |
| 339.44 | 2.51 | 2.51 |
| 248.33 | 1.69 | 1.69 |
| 343.88 | 4.13 | 4.13 |
| 514.59 | -1.04 | -1.04 |
| 322.48 | 4.63 | 4.63 |
| 214.23 | -0.25 | -0.25 |
| 244.38 | 3.15 | 3.15 |
| 610.67 | 6.32 | 6.32 |
| 440.46 | 4.03 | 4.03 |
| 514.63 | 7.26 | 7.26 |
| 340.47 | 2.93 | 2.93 |
| 277.50 | 5.30 | 5.30 |
| 339.39 | -0.24 | -0.24 |
| 307.39 | 2.57 | 2.57 |
| 432.60 | 4.19 | 4.19 |
| 415.50 | -0.32 | -0.32 |
| 159.23 | 1.08 | 1.08 |
| 418.57 | 4.59 | 4.59 |
| 427.53 | 4.11 | 4.11 |
| 411.57 | 3.49 | 3.49 |
| 246.35 | 2.73 | 2.73 |
| 204.23 | 1.30 | 1.30 |
| 179.22 | 0.72 | 0.72 |
| 311.47 | 3.96 | 3.96 |
| 290.37 | 0.26 | 0.26 |
| 500.43 | 8.64 | 8.64 |
| 448.39 | 4.86 | 4.86 |
| 309.49 | 4.40 | 4.40 |
| 291.44 | 4.71 | 4.71 |
| 424.53 | 2.44 | 2.44 |
| 462.51 | -0.23 | -0.23 |
| 367.88 | 2.09 | 2.09 |
| 317.43 | 3.24 | 3.24 |
| 287.36 | 1.92 | 1.92 |
| 220.32 | 2.32 | 2.32 |
| 294.39 | 2.56 | 2.56 |
| 339.42 | 0.70 | 0.70 |
| 308.42 | 2.95 | 2.95 |
| 378.41 | 0.49 | 0.49 |
| 192.26 | 2.51 | 2.51 |
| 212.25 | 3.04 | 3.04 |
| 213.24 | 2.66 | 2.66 |
| 461.47 | 2.64 | 2.64 |
| 372.81 | 3.14 | 3.14 |
| 452.60 | 5.22 | 5.22 |
| 170.21 | -0.13 | -0.13 |
| 315.48 | 4.27 | 4.27 |
| 163.20 | -0.49 | -0.49 |
| 195.69 | 2.59 | 2.59 |
| 606.78 | 8.68 | 8.68 |
| 349.41 | 0.32 | 0.32 |
| 373.46 | 2.07 | 2.07 |
| 363.50 | 3.31 | 3.31 |
| 206.28 | 3.07 | 3.07 |
| 314.47 | 5.85 | 5.85 |
| 286.34 | 1.09 | 1.09 |
| 416.58 | 4.85 | 4.85 |
| 435.89 | 2.52 | 2.52 |
| 211.27 | 1.80 | 1.80 |
| 293.37 | 2.93 | 2.93 |
| 137.16 | 0.32 | 0.32 |
| 315.42 | 1.16 | 1.16 |
| 488.02 | 3.31 | 3.31 |
| 407.32 | 2.02 | 2.02 |
| 454.52 | -0.64 | -0.64 |
| 424.39 | -0.54 | -0.54 |
| 453.88 | 2.69 | 2.69 |
| 480.57 | -1.28 | -1.28 |
| 602.68 | 7.33 | 7.33 |
| 135.13 | -0.11 | -0.11 |
| 204.30 | 2.15 | 2.15 |
| 259.22 | -2.70 | -2.70 |
| 369.49 | 1.29 | 1.29 |
| 308.33 | 3.61 | 3.61 |
| 459.51 | 2.70 | 2.70 |
| 392.58 | 4.48 | 4.48 |
| 481.55 | 2.40 | 2.40 |
| 212.25 | 0.94 | 0.94 |
| 342.30 | -5.40 | -5.40 |
| 335.47 | 2.20 | 2.20 |
| 324.40 | 3.81 | 3.81 |
| 269.31 | 0.38 | 0.38 |
| 434.50 | 2.27 | 2.27 |
| 293.73 | 4.16 | 4.16 |
| 324.46 | 4.05 | 4.05 |
| 461.50 | 0.09 | 0.09 |
| 392.58 | 4.48 | 4.48 |
| 404.82 | ||
| 492.53 | 4.28 | 4.28 |
| 268.27 | -1.18 | -1.18 |
| 301.39 | 1.73 | 1.73 |
| 349.41 | 0.35 | 0.35 |
| 575.63 | -1.40 | -1.40 |
| 460.51 | 2.43 | 2.43 |
| 420.51 | -1.60 | -1.60 |
| 285.69 | -0.30 | -0.30 |
| 441.40 | -0.04 | -0.04 |
| 776.87 | 4.56 | 4.56 |
| 228.25 | 2.63 | 2.63 |
| 363.39 | 0.15 | 0.15 |
| 402.49 | 2.56 | 2.56 |
| 863.36 | 17.85 | 17.85 |
| 645.68 | -1.11 | -1.11 |
| 473.45 | -0.73 | -0.73 |
| 116.07 | -0.29 | -0.29 |
| 539.64 | 3.62 | 3.62 |
| 455.47 | -0.62 | -0.62 |
| 627.75 | 5.81 | 5.81 |
| 321.83 | 3.67 | 3.67 |
| 359.35 | 0.76 | 0.76 |
| 450.35 | 5.04 | 5.04 |
| 386.45 | 2.38 | 2.38 |
| 446.64 | 3.18 | 3.18 |
| 143.23 | 1.54 | 1.54 |
| 414.34 | 4.87 | 4.87 |
| 510.48 | -0.17 | -0.17 |
| 414.50 | 3.12 | 3.12 |
| 466.98 | 4.10 | 4.10 |
| 532.57 | 4.46 | 4.46 |
| 485.95 | 4.39 | 4.39 |
| 270.76 | 2.42 | 2.42 |
| 328.45 | 1.67 | 1.67 |
| 305.37 | 2.37 | 2.37 |
| 486.44 | 4.61 | 4.61 |
| 243.17 | 3.05 | 3.05 |
| 380.87 | 5.87 | 5.87 |
| 183.25 | 1.13 | 1.13 |
| 415.57 | 3.15 | 3.15 |
| 557.61 | 0.83 | 0.83 |
| 451.62 | 3.19 | 3.19 |
| 471.55 | -0.73 | -0.73 |
| 307.44 | 4.42 | 4.42 |
| 404.51 | 2.42 | 2.42 |
| 388.46 | 2.58 | 2.58 |
| 177.25 | 0.98 | 0.98 |
| 474.55 | 2.22 | 2.22 |
| 357.42 | 6.14 | 6.14 |
| 382.53 | 5.31 | 5.31 |
| 753.00 | 8.71 | 8.71 |
| 382.54 | 4.26 | 4.26 |
| 190.16 | -1.03 | -1.03 |
| 322.50 | 4.39 | 4.39 |
| 288.18 | 2.86 | 2.86 |
| 837.06 | 2.21 | 2.21 |
| 488.33 | -2.23 | -2.23 |
| 492.69 | 4.26 | 4.26 |
| 572.56 | 5.71 | 5.71 |
| 185.23 | 2.15 | 2.15 |
| 321.16 | 4.09 | 4.09 |
| 436.96 | 4.19 | 4.19 |
| 386.48 | 4.64 | 4.64 |
| 298.35 | 1.53 | 1.53 |
| 379.89 | 1.60 | 1.60 |
| 325.84 | 4.33 | 4.33 |
| 190.16 | 1.85 | 1.85 |
| 465.57 | 1.74 | 1.74 |
| 288.35 | 3.93 | 3.93 |
| 218.27 | 0.49 | 0.49 |
| 387.23 | 1.78 | 1.78 |
| 466.41 | -2.88 | -2.88 |
| 556.66 | 1.32 | 1.32 |
| 392.88 | 1.90 | 1.90 |
| 482.63 | 4.77 | 4.77 |
| 476.54 | -1.04 | -1.04 |
| 813.98 | 2.62 | 2.62 |
| 546.94 | 4.51 | 4.51 |
| 452.41 | 4.75 | 4.75 |
| 382.89 | 1.18 | 1.18 |
| 284.36 | -2.67 | -2.67 |
| 574.99 | 4.99 | 4.99 |
| 501.51 | 5.54 | 5.54 |
| 470.54 | 2.67 | 2.67 |
| 527.53 | 3.85 | 3.85 |
| 238.33 | 3.27 | 3.27 |
| 379.50 | 3.86 | 3.86 |
| 144.13 | -0.11 | -0.11 |
| 380.53 | 3.89 | 3.89 |
| 339.33 | -0.80 | -0.80 |
| 293.45 | 4.50 | 4.50 |
| 426.59 | 1.57 | 1.57 |
| 372.55 | 6.26 | 6.26 |
| 411.47 | 4.63 | 4.63 |
| 2296.97 | ||
| 563.70 | 2.13 | 2.13 |
| 416.87 | 4.48 | 4.48 |
| 563.67 | 6.12 | 6.12 |
| 285.77 | 4.26 | 4.26 |
| 441.23 | 3.01 | 3.01 |
| 406.42 | 2.80 | 2.80 |
| 506.61 | 4.94 | 4.94 |
| 499.62 | 4.51 | 4.51 |
| 572.75 | 4.73 | 4.73 |
| 443.31 | 3.39 | 3.39 |
| 198.23 | -0.37 | -0.37 |
| 576.73 | 3.68 | 3.68 |
| 511.58 | 0.84 | 0.84 |
| 740.76 | 1.54 | 1.54 |