ID: ALA5291845
Type: Functional
Description: Antagonist activity at human NR1I2 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Bioactivity
Activity Types for Assay ALA5291845
AC50
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
135.21 | 1.58 | 1.58 |
441.55 | 4.37 | 4.37 |
430.38 | 2.88 | 2.88 |
249.35 | 2.15 | 2.15 |
252.27 | 1.77 | 1.77 |
804.03 | 4.64 | 4.64 |
454.61 | 5.09 | 5.09 |
398.40 | 3.70 | 3.70 |
416.36 | 1.89 | 1.89 |
581.67 | 1.99 | 1.99 |
263.38 | 3.83 | 3.83 |
212.25 | 0.79 | 0.79 |
375.87 | 4.43 | 4.43 |
278.44 | 5.66 | 5.66 |
395.48 | 3.22 | 3.22 |
223.28 | 2.68 | 2.68 |
272.37 | 1.09 | 1.09 |
243.39 | 4.33 | 4.33 |
267.25 | -1.98 | -1.98 |
266.39 | 3.53 | 3.53 |
232.28 | 1.35 | 1.35 |
276.42 | 3.75 | 3.75 |
371.52 | 6.00 | 6.00 |
654.61 | 3.19 | 3.19 |
410.49 | 3.59 | 3.59 |
354.49 | 3.48 | 3.48 |
316.43 | 0.50 | 0.50 |
308.34 | 2.52 | 2.52 |
275.35 | 1.77 | 1.77 |
228.25 | 2.03 | 2.03 |
440.95 | 4.63 | 4.63 |
339.48 | 3.36 | 3.36 |
264.32 | 2.47 | 2.47 |
333.36 | 1.61 | 1.61 |
206.28 | 3.07 | 3.07 |
383.41 | -0.56 | -0.56 |
314.50 | 4.27 | 4.27 |
733.94 | 1.79 | 1.79 |
398.48 | 3.33 | 3.33 |
265.35 | 1.99 | 1.99 |
426.49 | 4.83 | 4.83 |
352.47 | 3.25 | 3.25 |
399.44 | 2.87 | 2.87 |
393.44 | 3.41 | 3.41 |
404.35 | 2.04 | 2.04 |
260.25 | 1.11 | 1.11 |
179.26 | 2.03 | 2.03 |
463.80 | 5.94 | 5.94 |
238.33 | 2.85 | 2.85 |
351.35 | 1.80 | 1.80 |
151.16 | 1.35 | 1.35 |
254.28 | 3.40 | 3.40 |
348.40 | 1.13 | 1.13 |
395.46 | 2.55 | 2.55 |
260.38 | 2.85 | 2.85 |
356.45 | 3.16 | 3.16 |
336.48 | 4.14 | 4.14 |
357.44 | 2.49 | 2.49 |
207.23 | 1.31 | 1.31 |
163.20 | -0.49 | -0.49 |
131.13 | -0.62 | -0.62 |
575.69 | 5.70 | 5.70 |
241.68 | 0.82 | 0.82 |
339.39 | 3.86 | 3.86 |
382.54 | 3.95 | 3.95 |
246.31 | 2.79 | 2.79 |
146.24 | -1.92 | -1.92 |
291.73 | 2.85 | 2.85 |
230.31 | 3.30 | 3.30 |
396.45 | 0.59 | 0.59 |
407.58 | 5.68 | 5.68 |
354.47 | 1.70 | 1.70 |
337.35 | 1.12 | 1.12 |
352.45 | 2.70 | 2.70 |
383.47 | -0.31 | -0.31 |
412.56 | 5.80 | 5.80 |
277.41 | 4.17 | 4.17 |
341.45 | 3.24 | 3.24 |
277.41 | 3.04 | 3.04 |
381.91 | 4.30 | 4.30 |
323.13 | 0.91 | 0.91 |
255.36 | 3.72 | 3.72 |
405.44 | 2.36 | 2.36 |
414.35 | 3.44 | 3.44 |
265.36 | 2.48 | 2.48 |
315.37 | 1.05 | 1.05 |
277.41 | 4.21 | 4.21 |
189.22 | 0.16 | 0.16 |
183.21 | 0.35 | 0.35 |
367.81 | 0.62 | 0.62 |
295.30 | 2.97 | 2.97 |
296.15 | 4.36 | 4.36 |
296.41 | 3.61 | 3.61 |
218.10 | 0.86 | 0.86 |
136.20 | 0.84 | 0.84 |
213.66 | 1.86 | 1.86 |
387.48 | 0.72 | 0.72 |
475.36 | 4.43 | 4.43 |
229.26 | -0.59 | -0.59 |
312.44 | 3.44 | 3.44 |
331.87 | 4.88 | 4.88 |
270.76 | 3.63 | 3.63 |
386.53 | 4.66 | 4.66 |
379.50 | 2.89 | 2.89 |
406.48 | 3.74 | 3.74 |
211.18 | 0.02 | 0.02 |
429.56 | 4.60 | 4.60 |
234.20 | 2.78 | 2.78 |
308.38 | 0.53 | 0.53 |
347.22 | -1.86 | -1.86 |
303.83 | 4.19 | 4.19 |
260.38 | 2.85 | 2.85 |
295.38 | 1.53 | 1.53 |
160.22 | 1.23 | 1.23 |
299.35 | -0.18 | -0.18 |
199.16 | -1.10 | -1.10 |
327.47 | 3.37 | 3.37 |
284.75 | 2.61 | 2.61 |
586.20 | 8.95 | 8.95 |
612.63 | 3.63 | 3.63 |
454.45 | 0.27 | 0.27 |
369.47 | 3.46 | 3.46 |
230.26 | 3.04 | 3.04 |
378.32 | 4.45 | 4.45 |
219.24 | 1.46 | 1.46 |
142.16 | -0.91 | -0.91 |
158.16 | -1.94 | -1.94 |
194.15 | -2.08 | -2.08 |
319.25 | 3.93 | 3.93 |
317.23 | 3.84 | 3.84 |
246.31 | -0.28 | -0.28 |
182.17 | -0.23 | -0.23 |
404.49 | 3.80 | 3.80 |
621.93 | 4.63 | 4.63 |
263.79 | 3.96 | 3.96 |
435.44 | -1.17 | -1.17 |
546.59 | -1.30 | -1.30 |
368.30 | 2.01 | 2.01 |
220.28 | 1.37 | 1.37 |
292.14 | 1.76 | 1.76 |
470.61 | 6.33 | 6.33 |
218.26 | 1.47 | 1.47 |
290.79 | 3.40 | 3.40 |
314.37 | 2.96 | 2.96 |
588.56 | 1.34 | 1.34 |
348.44 | 2.12 | 2.12 |
1202.63 | ||
277.19 | 3.00 | 3.00 |
471.52 | 2.99 | 2.99 |
435.89 | 2.55 | 2.55 |
480.65 | 4.94 | 4.94 |
285.37 | 2.20 | 2.20 |
484.64 | 5.10 | 5.10 |
543.53 | 0.00 | 0.00 |
214.27 | 2.19 | 2.19 |
315.87 | 5.19 | 5.19 |
404.34 | 5.50 | 5.50 |
501.48 | 2.70 | 2.70 |
554.59 | -1.20 | -1.20 |
301.39 | 2.96 | 2.96 |
308.31 | 2.76 | 2.76 |
446.91 | 4.28 | 4.28 |
171.24 | 1.37 | 1.37 |
284.36 | 2.95 | 2.95 |
319.41 | 2.92 | 2.92 |
551.63 | 4.20 | 4.20 |
352.74 | 4.09 | 4.09 |
270.21 | 3.00 | 3.00 |
705.65 | 5.58 | 5.58 |
339.44 | 2.51 | 2.51 |
356.81 | 3.56 | 3.56 |
325.45 | 3.77 | 3.77 |
535.52 | 5.42 | 5.42 |
427.46 | 0.10 | 0.10 |
139.15 | 0.40 | 0.40 |
322.48 | 4.63 | 4.63 |
214.23 | -0.25 | -0.25 |
366.55 | 4.83 | 4.83 |
244.38 | 3.15 | 3.15 |
610.67 | 6.32 | 6.32 |
440.46 | 4.03 | 4.03 |
514.63 | 7.26 | 7.26 |
340.47 | 2.93 | 2.93 |
277.50 | 5.30 | 5.30 |
301.39 | 2.81 | 2.81 |
384.44 | 2.12 | 2.12 |
339.39 | -0.24 | -0.24 |
356.51 | 3.62 | 3.62 |
307.39 | 2.57 | 2.57 |
432.60 | 4.19 | 4.19 |
328.43 | 1.17 | 1.17 |
307.42 | 4.95 | 4.95 |
159.23 | 1.08 | 1.08 |
418.57 | 4.59 | 4.59 |
287.36 | 2.35 | 2.35 |
365.41 | 0.02 | 0.02 |
411.57 | 3.49 | 3.49 |
246.35 | 2.73 | 2.73 |
204.23 | 1.30 | 1.30 |
289.36 | 2.03 | 2.03 |
179.22 | 0.72 | 0.72 |
491.63 | 5.75 | 5.75 |
288.44 | 3.90 | 3.90 |
311.47 | 3.96 | 3.96 |
290.37 | 0.26 | 0.26 |
212.25 | 2.98 | 2.98 |
500.43 | 8.64 | 8.64 |
432.50 | 3.41 | 3.41 |
448.39 | 4.86 | 4.86 |
118.16 | -0.22 | -0.22 |
413.56 | 5.73 | 5.73 |
309.49 | 4.40 | 4.40 |
337.46 | 4.50 | 4.50 |
291.44 | 4.71 | 4.71 |
424.53 | 2.44 | 2.44 |
462.51 | -0.23 | -0.23 |
153.14 | 0.67 | 0.67 |
367.88 | 2.09 | 2.09 |
317.43 | 3.24 | 3.24 |
287.36 | 1.92 | 1.92 |
261.71 | 4.09 | 4.09 |
220.32 | 2.32 | 2.32 |
294.39 | 2.56 | 2.56 |
339.42 | 0.70 | 0.70 |
308.42 | 2.95 | 2.95 |
193.25 | 2.23 | 2.23 |
378.41 | 0.49 | 0.49 |
301.73 | 4.34 | 4.34 |
388.82 | 1.57 | 1.57 |
348.45 | 4.02 | 4.02 |
192.26 | 2.51 | 2.51 |
256.10 | 2.01 | 2.01 |
390.39 | 0.45 | 0.45 |
372.81 | 3.14 | 3.14 |
452.60 | 5.22 | 5.22 |
170.21 | -0.13 | -0.13 |
380.47 | 1.35 | 1.35 |
473.41 | 7.49 | 7.49 |
380.49 | 4.47 | 4.47 |
531.44 | 4.21 | 4.21 |
363.80 | 3.29 | 3.29 |
315.48 | 4.27 | 4.27 |
362.41 | 2.42 | 2.42 |
679.78 | -2.40 | -2.40 |
163.20 | -0.49 | -0.49 |
273.72 | 4.16 | 4.16 |
279.38 | 2.98 | 2.98 |
273.24 | 2.55 | 2.55 |
272.39 | 3.26 | 3.26 |
464.83 | 5.55 | 5.55 |
195.69 | 2.59 | 2.59 |
606.78 | 8.68 | 8.68 |
349.41 | 0.32 | 0.32 |
405.46 | 0.33 | 0.33 |
281.44 | 4.99 | 4.99 |
415.83 | 3.47 | 3.47 |
373.46 | 2.07 | 2.07 |
363.50 | 3.31 | 3.31 |
307.39 | 2.77 | 2.77 |
206.28 | 3.07 | 3.07 |
314.47 | 5.85 | 5.85 |
413.43 | 2.88 | 2.88 |
399.63 | 5.04 | 5.04 |
403.21 | 5.03 | 5.03 |
286.34 | 1.09 | 1.09 |
416.58 | 4.85 | 4.85 |
302.46 | 4.27 | 4.27 |
435.89 | 2.52 | 2.52 |
211.27 | 1.80 | 1.80 |
994.21 | -3.04 | -3.04 |
700.79 | 4.57 | 4.57 |
527.53 | 1.03 | 1.03 |
307.29 | 2.23 | 2.23 |
527.64 | 3.52 | 3.52 |
266.34 | 1.12 | 1.12 |
207.27 | 2.44 | 2.44 |
563.63 | 0.75 | 0.75 |
315.42 | 1.16 | 1.16 |
488.02 | 3.31 | 3.31 |
407.32 | 2.02 | 2.02 |
461.56 | 5.86 | 5.86 |
822.95 | 4.34 | 4.34 |
418.45 | 2.97 | 2.97 |
255.23 | -1.97 | -1.97 |
130.08 | -0.80 | -0.80 |
454.52 | -0.64 | -0.64 |
424.39 | -0.54 | -0.54 |
453.88 | 2.69 | 2.69 |
480.57 | -1.28 | -1.28 |
602.68 | 7.33 | 7.33 |
424.09 | 5.46 | 5.46 |
315.68 | 4.07 | 4.07 |
327.12 | 3.86 | 3.86 |
366.84 | 5.51 | 5.51 |
135.13 | -0.11 | -0.11 |
204.30 | 2.15 | 2.15 |
433.50 | 2.52 | 2.52 |
259.22 | -2.70 | -2.70 |
369.49 | 1.29 | 1.29 |
237.73 | 2.90 | 2.90 |
308.33 | 3.61 | 3.61 |
459.51 | 2.70 | 2.70 |
179.20 | -0.78 | -0.78 |
392.58 | 4.48 | 4.48 |
490.63 | 3.07 | 3.07 |
419.53 | 4.91 | 4.91 |
558.65 | 6.31 | 6.31 |
351.37 | 4.08 | 4.08 |
304.32 | 2.98 | 2.98 |
611.74 | 6.48 | 6.48 |
481.55 | 2.40 | 2.40 |
212.25 | 0.94 | 0.94 |
346.34 | 2.18 | 2.18 |
342.30 | -5.40 | -5.40 |
434.50 | 2.42 | 2.42 |
335.47 | 2.20 | 2.20 |
324.40 | 3.81 | 3.81 |
366.50 | 4.31 | 4.31 |
434.50 | 2.27 | 2.27 |
530.66 | 3.01 | 3.01 |
349.52 | 5.40 | 5.40 |
293.73 | 4.16 | 4.16 |
284.25 | 3.24 | 3.24 |
246.35 | 1.77 | 1.77 |
339.35 | 3.65 | 3.65 |
387.53 | -1.31 | -1.31 |
461.50 | 0.09 | 0.09 |
453.46 | -0.54 | -0.54 |
391.56 | 5.97 | 5.97 |
392.58 | 4.48 | 4.48 |
594.67 | -0.59 | -0.59 |
366.48 | 2.17 | 2.17 |
455.55 | 4.40 | 4.40 |
360.37 | 2.57 | 2.57 |
268.27 | -1.18 | -1.18 |
465.53 | 1.30 | 1.30 |
367.45 | 2.23 | 2.23 |
220.31 | 3.46 | 3.46 |
570.77 | 6.83 | 6.83 |
394.46 | 2.73 | 2.73 |
295.85 | 4.17 | 4.17 |
349.41 | 0.35 | 0.35 |
253.35 | 3.24 | 3.24 |
575.63 | -1.40 | -1.40 |
460.51 | 2.43 | 2.43 |
421.31 | 4.71 | 4.71 |
420.51 | -1.60 | -1.60 |
285.69 | -0.30 | -0.30 |
441.40 | -0.04 | -0.04 |
317.39 | 2.28 | 2.28 |
776.87 | 4.56 | 4.56 |
551.77 | 3.29 | 3.29 |
435.48 | 1.27 | 1.27 |
537.58 | 4.64 | 4.64 |
344.31 | -5.76 | -5.76 |
645.68 | -1.11 | -1.11 |
473.45 | -0.73 | -0.73 |
116.07 | -0.29 | -0.29 |
385.38 | 2.46 | 2.46 |
539.64 | 3.62 | 3.62 |
455.47 | -0.62 | -0.62 |
627.75 | 5.81 | 5.81 |
289.16 | 3.59 | 3.59 |
289.30 | 1.15 | 1.15 |
747.96 | 2.44 | 2.44 |
420.63 | 5.11 | 5.11 |
780.95 | 2.22 | 2.22 |
378.52 | 3.17 | 3.17 |
225.29 | 1.52 | 1.52 |
321.83 | 3.67 | 3.67 |
359.35 | 0.76 | 0.76 |
450.35 | 5.04 | 5.04 |
386.45 | 2.38 | 2.38 |
143.23 | 1.54 | 1.54 |
414.34 | 4.87 | 4.87 |
370.85 | 1.84 | 1.84 |
414.50 | 3.12 | 3.12 |
466.98 | 4.10 | 4.10 |
227.74 | 2.76 | 2.76 |
532.57 | 4.46 | 4.46 |
485.95 | 4.39 | 4.39 |
270.76 | 2.42 | 2.42 |
328.45 | 1.67 | 1.67 |
412.64 | 6.07 | 6.07 |
282.45 | 3.52 | 3.52 |
334.57 | 6.06 | 6.06 |
486.44 | 4.61 | 4.61 |
243.17 | 3.05 | 3.05 |
332.48 | 4.40 | 4.40 |
424.62 | 5.12 | 5.12 |
380.87 | 5.87 | 5.87 |
183.25 | 1.13 | 1.13 |
521.05 | 3.94 | 3.94 |
422.49 | 2.44 | 2.44 |
307.44 | 4.42 | 4.42 |
557.84 | 5.97 | 5.97 |
511.57 | -0.87 | -0.87 |
404.51 | 2.42 | 2.42 |
177.25 | 0.98 | 0.98 |
474.55 | 2.22 | 2.22 |
181.21 | -0.60 | -0.60 |
753.00 | 8.71 | 8.71 |
274.80 | 3.82 | 3.82 |
382.54 | 4.26 | 4.26 |
421.47 | 4.52 | 4.52 |
238.20 | 0.70 | 0.70 |
215.29 | 1.42 | 1.42 |
456.35 | -1.61 | -1.61 |
441.52 | 2.56 | 2.56 |
322.50 | 4.39 | 4.39 |
837.06 | 2.21 | 2.21 |
193.20 | 0.89 | 0.89 |
356.23 | 0.40 | 0.40 |
492.69 | 4.26 | 4.26 |
390.52 | 3.58 | 3.58 |
216.28 | 2.14 | 2.14 |
572.56 | 5.71 | 5.71 |
1058.05 | ||
185.23 | 2.15 | 2.15 |
376.42 | 2.35 | 2.35 |
321.16 | 4.09 | 4.09 |
515.54 | -2.49 | -2.49 |
236.31 | 0.16 | 0.16 |
436.96 | 4.19 | 4.19 |
454.87 | 5.64 | 5.64 |
342.86 | 4.20 | 4.20 |
386.48 | 4.64 | 4.64 |
242.24 | 0.09 | 0.09 |
312.76 | 3.82 | 3.82 |
396.57 | 3.89 | 3.89 |
298.35 | 1.53 | 1.53 |
221.30 | 2.74 | 2.74 |
325.84 | 4.33 | 4.33 |
450.53 | 5.74 | 5.74 |
340.46 | 4.37 | 4.37 |
465.57 | 1.74 | 1.74 |
370.49 | 4.19 | 4.19 |
244.27 | -0.75 | -0.75 |
295.45 | 4.68 | 4.68 |
218.27 | 0.49 | 0.49 |
266.26 | -1.19 | -1.19 |
294.35 | 1.19 | 1.19 |
257.22 | -1.45 | -1.45 |
371.83 | 2.30 | 2.30 |
349.82 | 1.52 | 1.52 |
400.65 | 6.59 | 6.59 |
345.85 | 1.90 | 1.90 |
466.41 | -2.88 | -2.88 |
354.47 | 3.09 | 3.09 |
279.34 | 2.89 | 2.89 |
556.66 | 1.32 | 1.32 |
203.24 | -1.24 | -1.24 |
249.31 | -0.05 | -0.05 |
288.39 | 3.05 | 3.05 |
392.88 | 1.90 | 1.90 |
141.26 | 2.34 | 2.34 |
365.48 | 3.34 | 3.34 |
145.54 | 1.15 | 1.15 |
482.63 | 4.77 | 4.77 |
298.36 | 3.76 | 3.76 |
295.34 | 3.43 | 3.43 |
264.32 | 1.89 | 1.89 |
308.42 | 3.72 | 3.72 |
440.51 | 4.22 | 4.22 |
193.20 | 1.27 | 1.27 |
468.59 | 6.20 | 6.20 |
248.20 | 2.00 | 2.00 |
482.82 | 5.69 | 5.69 |
291.69 | 3.48 | 3.48 |
330.51 | 6.47 | 6.47 |
385.49 | 2.98 | 2.98 |
563.58 | 6.32 | 6.32 |
312.45 | 3.88 | 3.88 |
406.50 | 1.71 | 1.71 |
546.94 | 4.51 | 4.51 |
452.41 | 4.75 | 4.75 |
402.50 | 3.13 | 3.13 |
231.29 | 1.62 | 1.62 |
395.38 | 3.33 | 3.33 |
284.36 | -2.67 | -2.67 |
383.47 | 0.73 | 0.73 |
574.99 | 4.99 | 4.99 |
501.51 | 5.54 | 5.54 |
522.57 | -3.16 | -3.16 |
283.33 | 0.76 | 0.76 |
313.34 | 0.95 | 0.95 |
412.88 | 4.51 | 4.51 |
527.53 | 3.85 | 3.85 |
238.33 | 3.27 | 3.27 |
379.50 | 3.86 | 3.86 |
246.31 | 1.81 | 1.81 |
144.13 | -0.11 | -0.11 |
284.44 | 4.31 | 4.31 |
374.37 | 2.53 | 2.53 |
380.53 | 3.89 | 3.89 |
358.44 | 2.57 | 2.57 |
339.33 | -0.80 | -0.80 |
469.95 | 5.16 | 5.16 |
426.59 | 1.57 | 1.57 |
415.43 | 3.75 | 3.75 |
713.14 | 14.57 | 14.57 |
411.47 | 4.63 | 4.63 |
416.87 | 4.48 | 4.48 |
868.46 | 8.66 | 8.66 |
466.46 | 2.63 | 2.63 |
285.77 | 4.26 | 4.26 |
441.23 | 3.01 | 3.01 |
406.42 | 2.80 | 2.80 |
506.61 | 4.94 | 4.94 |
666.91 | 5.48 | 5.48 |
499.62 | 4.51 | 4.51 |
572.75 | 4.73 | 4.73 |
520.50 | 3.40 | 3.40 |
443.31 | 3.39 | 3.39 |
217.22 | -1.83 | -1.83 |
280.41 | 1.65 | 1.65 |
530.51 | 5.75 | 5.75 |
434.53 | 4.60 | 4.60 |
398.50 | 3.58 | 3.58 |