Basic Information
ID: ALA644757
Type: ADME
Description: Inhibitory potency to aminopyrine N-demethylase activity (P450) in hepatic microsomes from phenobarbitone-induced rats.
Organism: Rattus norvegicus
Tissue: Liver
Subcellular Fraction: Microsomes
Activity Charts
Bioactivity
Activity Types for Assay ALA644757
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 186.14 | 2.58 | 2.58 |
| 147.18 | 1.02 | 1.02 |
| 201.06 | 3.18 | 3.18 |
| 187.03 | 2.87 | 2.87 |
| 118.14 | 1.56 | 1.56 |
| 132.17 | 1.87 | 1.87 |
| 152.58 | 2.22 | 2.22 |
| 166.61 | 2.52 | 2.52 |
| 195.22 | 2.62 | 2.62 |
| 195.22 | 2.62 | 2.62 |
| 194.24 | 3.23 | 3.23 |
| 132.17 | 1.87 | 1.87 |
| 174.25 | 2.74 | 2.74 |
| 188.27 | 3.30 | 3.30 |
| 146.19 | 2.13 | 2.13 |
| 216.33 | 4.08 | 4.08 |
| 272.44 | 5.64 | 5.64 |
| 160.22 | 2.49 | 2.49 |
| 146.19 | 2.18 | 2.18 |
| 160.22 | 2.52 | 2.52 |
| 163.14 | 1.47 | 1.47 |
| 177.16 | 1.78 | 1.78 |
| 166.61 | 2.30 | 2.30 |
| 231.30 | 3.00 | 3.00 |
| 277.15 | 4.46 | 4.46 |
| 238.29 | 3.45 | 3.45 |
| 250.34 | 4.13 | 4.13 |
| 236.32 | 3.74 | 3.74 |
| 222.29 | 3.35 | 3.35 |
| 197.58 | 2.12 | 2.12 |
| 238.29 | 3.45 | 3.45 |
| 208.26 | 3.15 | 3.15 |
| 224.26 | 2.64 | 2.64 |
| 244.38 | 4.69 | 4.69 |
| 202.30 | 3.52 | 3.52 |
| 176.22 | 2.27 | 2.27 |
| 252.32 | 3.76 | 3.76 |
| 238.29 | 3.18 | 3.18 |
| 160.22 | 2.43 | 2.43 |
| 300.49 | 6.42 | 6.42 |
| 230.35 | 4.38 | 4.38 |
| 258.71 | 3.80 | 3.80 |
| 303.16 | 3.90 | 3.90 |
| 252.32 | 3.70 | 3.70 |
| 286.76 | 4.41 | 4.41 |
| 252.32 | 3.76 | 3.76 |
| 146.19 | 2.18 | 2.18 |
| 132.17 | 1.87 | 1.87 |
| 382.06 | 4.67 | 4.67 |
| 382.06 | 4.67 | 4.67 |
| 303.16 | 3.90 | 3.90 |
| 230.35 | 4.47 | 4.47 |
| 187.03 | 2.87 | 2.87 |
| 224.26 | 3.14 | 3.14 |
| 163.14 | 1.47 | 1.47 |
| 211.61 | 2.43 | 2.43 |
| 223.66 | 2.48 | 2.48 |
| 174.25 | 2.91 | 2.91 |
| 245.33 | 3.25 | 3.25 |
| 189.22 | 1.83 | 1.83 |
| 200.28 | 3.61 | 3.61 |
| 202.30 | 3.69 | 3.69 |
| 258.32 | 4.31 | 4.31 |
| 258.32 | 4.31 | 4.31 |
| 158.20 | 2.44 | 2.44 |
| 160.22 | 2.69 | 2.69 |
| 136.13 | 1.70 | 1.70 |
| 174.25 | 2.86 | 2.86 |
| 174.25 | 2.76 | 2.76 |
| 236.32 | 3.77 | 3.77 |
| 258.71 | 3.80 | 3.80 |
| 251.29 | 3.12 | 3.12 |
| 160.22 | 2.49 | 2.49 |
| 242.71 | 3.81 | 3.81 |
| 222.25 | 2.79 | 2.79 |
| 271.71 | 3.47 | 3.47 |
| 188.27 | 3.13 | 3.13 |
| 293.15 | 4.45 | 4.45 |
| 218.26 | 2.20 | 2.20 |
| 168.20 | 1.05 | 1.05 |
| 201.06 | 3.18 | 3.18 |
| 162.19 | 1.96 | 1.96 |