Basic Information
ID: ALA669614
Type: Binding
Description: Inhibitory activity against dihydrofolate reductase (DHFR) isolated from murine L5178Y tumor cells resistant and sensitive to methotrexate
Cell type: L5178Y
Activity Charts
Bioactivity
Activity Types for Assay ALA669614
Log 1/C
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 259.31 | 1.07 | 1.07 |
| 285.27 | 1.89 | 1.89 |
| 231.30 | 1.18 | 1.18 |
| 231.30 | 1.18 | 1.18 |
| 247.30 | 0.88 | 0.88 |
| 392.29 | 3.76 | 3.76 |
| 273.38 | 2.17 | 2.17 |
| 449.48 | 4.13 | 4.13 |
| 247.30 | 0.88 | 0.88 |
| 353.43 | 2.33 | 2.33 |
| 235.27 | 1.01 | 1.01 |
| 273.38 | 2.21 | 2.21 |
| 235.27 | 1.01 | 1.01 |
| 381.48 | 3.11 | 3.11 |
| 285.27 | 1.89 | 1.89 |
| 296.17 | 1.63 | 1.63 |
| 217.28 | 0.87 | 0.87 |
| 290.32 | 1.26 | 1.26 |
| 259.31 | 1.07 | 1.07 |
| 343.17 | 1.48 | 1.48 |
| 296.36 | -0.48 | -0.48 |
| 296.17 | 1.63 | 1.63 |
| 289.38 | 2.05 | 2.05 |
| 323.40 | 2.45 | 2.45 |
| 323.40 | 2.45 | 2.45 |
| 392.29 | 3.76 | 3.76 |
| 296.36 | -0.48 | -0.48 |
| 251.72 | 1.53 | 1.53 |
| 273.38 | 2.17 | 2.17 |
| 343.17 | 1.48 | 1.48 |
| 76.05 | -0.96 | -0.96 |
| 300.05 | ||
| 334.33 | -1.65 | -1.65 |
| 373.91 | 3.82 | 3.82 |
| 386.36 | ||
| 348.41 | 2.32 | 2.32 |
| 262.27 | 0.78 | 0.78 |
| 233.28 | 0.58 | 0.58 |
| 381.52 | 3.47 | 3.47 |
| 421.42 | 3.35 | 3.35 |
| 408.47 | 0.68 | 0.68 |
| 393.54 | 4.18 | 4.18 |
| 426.74 | 4.41 | 4.41 |
| 399.50 | 4.12 | 4.12 |
| 373.46 | 3.60 | 3.60 |
| 401.50 | 1.13 | 1.13 |
| 365.48 | 3.57 | 3.57 |
| 351.45 | 3.01 | 3.01 |
| 337.43 | 2.76 | 2.76 |
| 353.43 | 1.94 | 1.94 |
| 429.65 | 5.95 | 5.95 |
| 387.57 | 4.78 | 4.78 |
| 359.52 | 4.00 | 4.00 |
| 339.47 | 3.16 | 3.16 |
| 339.47 | 3.16 | 3.16 |
| 317.44 | 2.83 | 2.83 |
| 381.44 | 1.94 | 1.94 |
| 380.45 | 2.41 | 2.41 |
| 385.60 | 5.34 | 5.34 |
| 343.52 | 4.17 | 4.17 |
| 245.33 | 1.43 | 1.43 |
| 353.43 | 2.46 | 2.46 |
| 323.40 | 1.95 | 1.95 |
| 357.85 | 3.10 | 3.10 |
| 261.33 | 1.27 | 1.27 |
| 251.72 | 1.53 | 1.53 |
| 334.38 | 1.27 | 1.27 |
| 301.44 | 2.99 | 2.99 |
| 274.33 | 0.83 | 0.83 |
| 360.42 | 0.11 | 0.11 |
| 317.40 | 2.27 | 2.27 |
| 233.28 | 0.58 | 0.58 |
| 317.44 | 2.83 | 2.83 |
| 323.40 | 2.45 | 2.45 |
| 415.63 | 5.56 | 5.56 |
| 373.46 | 3.60 | 3.60 |
| 401.60 | 5.17 | 5.17 |
| 329.45 | 2.72 | 2.72 |
| 286.17 | 2.18 | 2.18 |
| 353.50 | 3.47 | 3.47 |
| 275.36 | 1.66 | 1.66 |
| 232.29 | 0.45 | 0.45 |
| 313.48 | ||
| 241.30 | 0.85 | 0.85 |
| 343.52 | 4.17 | 4.17 |
| 242.29 | 0.74 | 0.74 |
| 397.51 | 2.73 | 2.73 |
| 379.51 | 3.75 | 3.75 |
| 353.43 | 1.94 | 1.94 |
| 303.41 | 2.44 | 2.44 |
| 366.43 | 1.55 | 1.55 |
| 368.44 | 1.91 | 1.91 |
| 366.43 | 1.55 | 1.55 |
| 402.48 | 1.10 | 1.10 |
| 275.36 | 1.66 | 1.66 |
| 387.57 | 4.78 | 4.78 |
| 260.30 | -0.03 | -0.03 |
| 295.37 | 0.28 | 0.28 |
| 401.60 | 5.17 | 5.17 |
| 243.22 | -2.56 | -2.56 |
| 543.53 | 0.00 | 0.00 |
| 245.33 | 1.49 | 1.49 |
| 261.33 | 1.27 | 1.27 |
| 289.38 | 2.05 | 2.05 |
| 345.49 | 3.61 | 3.61 |
| 273.34 | 1.44 | 1.44 |
| 527.53 | 1.03 | 1.03 |
| 1255.44 | ||
| 471.52 | -0.79 | -0.79 |