Basic Information
ID: ALA682357
Type: Functional
Description: Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
Cell type: CHO
Activity Charts
Bioactivity
Activity Types for Assay ALA682357
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 483.32 | 2.58 | 2.58 |
| 450.52 | 2.54 | 2.54 |
| 581.88 | 6.56 | 6.56 |
| 508.58 | 4.01 | 4.01 |
| 561.47 | 6.21 | 6.21 |
| 575.49 | 6.52 | 6.52 |
| 577.46 | 5.91 | 5.91 |
| 552.63 | 4.32 | 4.32 |
| 547.44 | 5.91 | 5.91 |
| 614.70 | 5.68 | 5.68 |
| 607.49 | 5.92 | 5.92 |
| 594.71 | 5.36 | 5.36 |
| 561.47 | 6.21 | 6.21 |
| 561.47 | 6.21 | 6.21 |
| 653.57 | 6.98 | 6.98 |
| 543.02 | 4.66 | 4.66 |
| 581.88 | 6.56 | 6.56 |
| 522.61 | 4.31 | 4.31 |
| 502.62 | 4.39 | 4.39 |
| 522.61 | 4.31 | 4.31 |
| 500.52 | 1.52 | 1.52 |
| 476.49 | 1.89 | 1.89 |
| 566.66 | 4.58 | 4.58 |
| 568.63 | 4.02 | 4.02 |
| 606.60 | 5.03 | 5.03 |
| 404.43 | 1.82 | 1.82 |
| 460.53 | 2.94 | 2.94 |
| 504.54 | 2.67 | 2.67 |
| 434.45 | 1.83 | 1.83 |
| 617.12 | 6.14 | 6.14 |
| 618.66 | 5.77 | 5.77 |
| 405.45 | 2.85 | 2.85 |
| 472.55 | 3.22 | 3.22 |
| 506.56 | 2.43 | 2.43 |
| 403.48 | 3.41 | 3.41 |
| 522.61 | 4.05 | 4.05 |
| 462.50 | 3.05 | 3.05 |
| 536.63 | 4.44 | 4.44 |
| 492.53 | 3.05 | 3.05 |
| 577.46 | 5.91 | 5.91 |
| 544.56 | 4.28 | 4.28 |
| 526.57 | 4.14 | 4.14 |
| 587.47 | 4.77 | 4.77 |
| 556.59 | 4.15 | 4.15 |
| 544.65 | 4.55 | 4.55 |
| 562.55 | 4.42 | 4.42 |
| 577.47 | 5.31 | 5.31 |
| 561.01 | 4.80 | 4.80 |
| 496.95 | 3.70 | 3.70 |
| 562.55 | 4.42 | 4.42 |
| 432.48 | 2.44 | 2.44 |
| 496.95 | 3.70 | 3.70 |
| 544.56 | 4.28 | 4.28 |
| 544.56 | 4.28 | 4.28 |
| 543.02 | 4.66 | 4.66 |
| 526.57 | 4.14 | 4.14 |
| 562.55 | 4.42 | 4.42 |
| 562.55 | 4.42 | 4.42 |
| 522.61 | 4.31 | 4.31 |
| 587.47 | 4.77 | 4.77 |
| 522.55 | 3.06 | 3.06 |
| 526.57 | 4.14 | 4.14 |
| 592.57 | 4.90 | 4.90 |
| 576.58 | 5.02 | 5.02 |
| 544.56 | 4.28 | 4.28 |
| 570.62 | 4.46 | 4.46 |
| 566.66 | 4.63 | 4.63 |
| 592.57 | 4.90 | 4.90 |
| 576.58 | 5.02 | 5.02 |
| 514.63 | 4.39 | 4.39 |
| 528.65 | 4.78 | 4.78 |
| 543.02 | 4.66 | 4.66 |
| 489.58 | 2.37 | 2.37 |
| 531.61 | 2.14 | 2.14 |
| 566.61 | 3.79 | 3.79 |
| 552.63 | 4.32 | 4.32 |
| 573.05 | 4.67 | 4.67 |
| 584.68 | 5.67 | 5.67 |
| 462.51 | 1.80 | 1.80 |
| 560.57 | 5.63 | 5.63 |
| 564.69 | 5.30 | 5.30 |
| 564.69 | 5.35 | 5.35 |
| 552.59 | 3.70 | 3.70 |
| 556.59 | 4.15 | 4.15 |
| 538.60 | 4.01 | 4.01 |
| 562.55 | 4.42 | 4.42 |
| 544.56 | 4.28 | 4.28 |
| 592.57 | 4.90 | 4.90 |
| 576.58 | 5.02 | 5.02 |
| 550.66 | 4.93 | 4.93 |
| 378.43 | 3.52 | 3.52 |
| 559.04 | 6.01 | 6.01 |
| 638.65 | 6.09 | 6.09 |
| 606.77 | 6.27 | 6.27 |
| 544.56 | 4.28 | 4.28 |
| 464.48 | 1.84 | 1.84 |
| 456.51 | 2.86 | 2.86 |
| 499.53 | 3.16 | 3.16 |
| 575.49 | 6.52 | 6.52 |
| 575.49 | 6.52 | 6.52 |
| 589.52 | 7.03 | 7.03 |
| 598.53 | 4.70 | 4.70 |
| 532.64 | 4.55 | 4.55 |
| 500.52 | 2.18 | 2.18 |