Basic Information
ID: ALA875079
Type: Functional
Description: Antagonistic activity by ability to block serotonin induced relaxation (mediated by activation of 5-hydroxytryptamine 4 receptor) in carbamylcholine (10e-6 M) contracted esophagus at a concentration of 10e-6 M.
Format: BAO_0000221
Tissue: Esophagus
Target: Serotonin 4 (5-HT4) receptor(ALA4317)
Document: ALA1131384
Antagonistic activity by ability to block serotonin induced relaxation (mediated by activation of 5-hydroxytryptamine 4 receptor) in carbamylcholine (10e-6 M) contracted esophagus at a concentration of 10e-6 M.: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA875079
Relaxation
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 284.36 | 2.95 | 2.95 |
| 463.58 | 3.74 | 3.74 |
| 447.58 | 3.17 | 3.17 |
| 433.56 | 3.24 | 3.24 |
| 286.38 | 2.10 | 2.10 |
| 316.41 | 2.04 | 2.04 |
| 438.55 | 4.42 | 4.42 |
| 418.59 | 4.83 | 4.83 |
| 404.56 | 4.44 | 4.44 |
| 356.47 | 2.96 | 2.96 |
| 390.53 | 4.05 | 4.05 |
| 464.59 | 4.95 | 4.95 |
| 323.82 | 2.29 | 2.29 |
| 376.50 | 4.01 | 4.01 |
| 328.46 | 3.22 | 3.22 |
| 480.58 | 4.55 | 4.55 |
| 404.56 | 4.30 | 4.30 |
| 342.44 | 2.57 | 2.57 |
| 342.44 | 2.40 | 2.40 |
| 314.39 | 1.52 | 1.52 |
| 407.54 | 1.36 | 1.36 |
| 462.60 | 3.31 | 3.31 |
| 466.56 | 3.77 | 3.77 |
| 448.57 | 3.63 | 3.63 |
| 433.56 | 3.24 | 3.24 |
| 407.54 | 1.36 | 1.36 |
| 283.37 | 2.52 | 2.52 |
| 297.40 | 2.53 | 2.53 |
| 459.55 | 3.11 | 3.11 |
| 339.48 | 3.97 | 3.97 |
| 326.44 | 2.97 | 2.97 |
| 432.61 | 5.22 | 5.22 |
| 325.46 | 3.58 | 3.58 |
| 325.46 | 3.41 | 3.41 |
| 311.43 | 3.02 | 3.02 |
| 413.57 | 2.97 | 2.97 |
| 362.48 | 3.41 | 3.41 |
| 419.53 | 2.81 | 2.81 |
| 405.55 | 3.16 | 3.16 |
| 316.41 | 1.68 | 1.68 |
| 371.49 | 1.95 | 1.95 |
| 329.45 | 1.77 | 1.77 |
| 326.44 | 2.80 | 2.80 |
| 312.42 | 2.41 | 2.41 |
| 302.42 | 2.69 | 2.69 |
| 491.68 | 4.14 | 4.14 |
| 342.49 | 3.61 | 3.61 |
| 328.46 | 3.22 | 3.22 |
| 300.41 | 2.44 | 2.44 |
| 465.95 | 3.36 | 3.36 |
| 348.87 | 3.41 | 3.41 |