Basic Information
ID: ALA944853
Type: Binding
Description: Selectivity for BACE1 over cathepsin D
Activity Charts
Bioactivity
Activity Types for Assay ALA944853
Ratio IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 318.38 | 2.83 | 2.83 |
| 352.83 | 3.49 | 3.49 |
| 352.83 | 3.49 | 3.49 |
| 397.28 | 3.59 | 3.59 |
| 332.41 | 3.14 | 3.14 |
| 332.41 | 3.14 | 3.14 |
| 348.41 | 2.84 | 2.84 |
| 387.27 | 4.14 | 4.14 |
| 410.48 | 4.62 | 4.62 |
| 452.51 | 4.83 | 4.83 |
| 424.50 | 4.41 | 4.41 |
| 368.44 | 3.98 | 3.98 |
| 382.47 | 4.29 | 4.29 |
| 387.27 | 4.14 | 4.14 |
| 387.27 | 4.14 | 4.14 |
| 431.72 | 4.25 | 4.25 |
| 366.85 | 3.79 | 3.79 |
| 366.85 | 3.79 | 3.79 |
| 421.71 | 4.79 | 4.79 |
| 444.92 | 5.28 | 5.28 |
| 486.96 | 5.48 | 5.48 |
| 458.95 | 5.06 | 5.06 |
| 402.89 | 4.64 | 4.64 |
| 416.91 | 4.95 | 4.95 |
| 348.41 | 2.84 | 2.84 |
| 382.85 | 3.49 | 3.49 |
| 382.85 | 3.49 | 3.49 |
| 427.30 | 3.60 | 3.60 |
| 362.43 | 3.15 | 3.15 |
| 362.43 | 3.15 | 3.15 |
| 378.43 | 2.85 | 2.85 |
| 417.30 | 4.15 | 4.15 |
| 440.50 | 4.63 | 4.63 |
| 482.54 | 4.84 | 4.84 |
| 398.47 | 3.99 | 3.99 |
| 412.49 | 4.30 | 4.30 |
| 336.37 | 2.97 | 2.97 |
| 370.82 | 3.62 | 3.62 |
| 370.82 | 3.62 | 3.62 |
| 415.27 | 3.73 | 3.73 |
| 350.40 | 3.28 | 3.28 |
| 350.40 | 3.28 | 3.28 |
| 366.40 | 2.98 | 2.98 |
| 405.26 | 4.28 | 4.28 |
| 428.47 | 4.76 | 4.76 |
| 470.50 | 4.97 | 4.97 |
| 442.49 | 4.55 | 4.55 |
| 386.43 | 4.12 | 4.12 |
| 400.46 | 4.43 | 4.43 |
| 444.92 | 5.28 | 5.28 |
| 348.41 | 2.84 | 2.84 |
| 382.85 | 3.49 | 3.49 |
| 382.85 | 3.49 | 3.49 |
| 362.43 | 3.15 | 3.15 |
| 362.43 | 3.15 | 3.15 |
| 378.43 | 2.85 | 2.85 |
| 417.30 | 4.15 | 4.15 |
| 440.50 | 4.63 | 4.63 |
| 482.54 | 4.84 | 4.84 |
| 454.53 | 4.42 | 4.42 |
| 398.47 | 3.99 | 3.99 |
| 412.49 | 4.30 | 4.30 |
| 343.39 | 2.70 | 2.70 |
| 377.83 | 3.36 | 3.36 |
| 377.83 | 3.36 | 3.36 |
| 422.29 | 3.47 | 3.47 |
| 357.42 | 3.01 | 3.01 |
| 357.42 | 3.01 | 3.01 |
| 373.42 | 2.71 | 2.71 |
| 412.28 | 4.01 | 4.01 |
| 435.49 | 4.50 | 4.50 |
| 477.52 | 4.70 | 4.70 |
| 449.51 | 4.28 | 4.28 |
| 393.45 | 3.86 | 3.86 |
| 407.48 | 4.17 | 4.17 |
| 336.37 | 2.97 | 2.97 |
| 370.82 | 3.62 | 3.62 |
| 370.82 | 3.62 | 3.62 |
| 415.27 | 3.73 | 3.73 |
| 350.40 | 3.28 | 3.28 |
| 350.40 | 3.28 | 3.28 |
| 366.40 | 2.98 | 2.98 |
| 405.26 | 4.28 | 4.28 |
| 428.47 | 4.76 | 4.76 |
| 470.50 | 4.97 | 4.97 |
| 442.49 | 4.55 | 4.55 |
| 386.43 | 4.12 | 4.12 |
| 400.46 | 4.43 | 4.43 |
| 382.85 | 3.49 | 3.49 |
| 382.85 | 3.49 | 3.49 |
| 427.30 | 3.60 | 3.60 |
| 362.43 | 3.15 | 3.15 |
| 362.43 | 3.15 | 3.15 |
| 378.43 | 2.85 | 2.85 |
| 417.30 | 4.15 | 4.15 |
| 440.50 | 4.63 | 4.63 |
| 482.54 | 4.84 | 4.84 |
| 398.47 | 3.99 | 3.99 |
| 412.49 | 4.30 | 4.30 |
| 386.38 | 3.85 | 3.85 |
| 420.82 | 4.50 | 4.50 |
| 420.82 | 4.50 | 4.50 |
| 465.27 | 4.61 | 4.61 |
| 400.40 | 4.16 | 4.16 |
| 400.40 | 4.16 | 4.16 |
| 416.40 | 3.86 | 3.86 |
| 455.27 | 5.16 | 5.16 |
| 478.47 | 5.64 | 5.64 |
| 520.51 | 5.85 | 5.85 |
| 492.50 | 5.43 | 5.43 |
| 436.44 | 5.00 | 5.00 |
| 450.46 | 5.31 | 5.31 |
| 368.44 | 3.98 | 3.98 |
| 402.89 | 4.64 | 4.64 |
| 402.89 | 4.64 | 4.64 |
| 447.34 | 4.75 | 4.75 |
| 382.47 | 4.29 | 4.29 |
| 382.47 | 4.29 | 4.29 |
| 398.47 | 3.99 | 3.99 |
| 437.33 | 5.29 | 5.29 |
| 418.50 | 5.14 | 5.14 |
| 408.91 | 4.70 | 4.70 |
| 408.91 | 4.70 | 4.70 |
| 453.37 | 4.81 | 4.81 |
| 388.50 | 4.35 | 4.35 |
| 404.50 | 4.06 | 4.06 |
| 466.57 | 5.84 | 5.84 |
| 480.59 | 5.63 | 5.63 |
| 424.53 | 5.20 | 5.20 |
| 375.43 | 2.79 | 2.79 |
| 389.46 | 3.18 | 3.18 |
| 401.47 | 3.18 | 3.18 |
| 417.51 | 3.82 | 3.82 |
| 443.55 | 4.35 | 4.35 |
| 506.39 | 5.39 | 5.39 |
| 516.40 | 4.85 | 4.85 |
| 467.53 | 4.09 | 4.09 |
| 516.40 | 4.85 | 4.85 |
| 469.52 | 4.15 | 4.15 |
| 411.49 | 2.20 | 2.20 |
| 425.51 | 2.59 | 2.59 |
| 439.54 | 2.98 | 2.98 |
| 487.59 | 3.77 | 3.77 |
| 503.58 | 3.64 | 3.64 |
| 552.45 | 4.40 | 4.40 |
| 487.59 | 3.94 | 3.94 |
| 362.43 | 3.23 | 3.23 |
| 374.44 | 3.40 | 3.40 |
| 372.43 | 2.84 | 2.84 |
| 401.47 | 3.51 | 3.51 |
| 390.49 | 4.01 | 4.01 |
| 449.51 | 4.28 | 4.28 |
| 438.53 | 4.45 | 4.45 |