Basic Information
ID: ALA974344
Type: Functional
Description: Inhibition of MMP13-induced cartilage degradation in rat assessed as chondroitin sulfate release at 30 mg/kg, po administered 4 hrs before MMP13 challenge injected intra-articularly measured after 2 hrs by ELISA
Organism: Rattus norvegicus
Activity Charts
Bioactivity
Activity Types for Assay ALA974344
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 425.89 | 3.21 | 3.21 |
| 436.55 | 1.99 | 1.99 |
| 504.61 | 3.74 | 3.74 |
| 429.93 | 1.81 | 1.81 |
| 523.68 | 3.86 | 3.86 |
| 423.56 | 2.21 | 2.21 |
| 480.61 | 3.79 | 3.79 |
| 524.66 | 4.19 | 4.19 |
| 540.66 | 3.81 | 3.81 |
| 481.60 | 3.19 | 3.19 |
| 481.60 | 3.19 | 3.19 |
| 511.62 | 3.20 | 3.20 |
| 517.65 | 3.80 | 3.80 |
| 549.72 | 4.39 | 4.39 |
| 466.58 | 3.40 | 3.40 |
| 482.58 | 3.11 | 3.11 |
| 496.61 | 3.41 | 3.41 |
| 550.58 | 4.30 | 4.30 |
| 510.63 | 3.80 | 3.80 |
| 524.66 | 4.19 | 4.19 |
| 524.66 | 4.19 | 4.19 |
| 540.66 | 3.43 | 3.43 |
| 480.61 | 3.71 | 3.71 |
| 534.58 | 4.42 | 4.42 |
| 482.58 | 3.02 | 3.02 |
| 496.61 | 3.41 | 3.41 |
| 510.63 | 3.80 | 3.80 |
| 524.66 | 4.19 | 4.19 |
| 524.66 | 4.05 | 4.05 |
| 538.69 | 4.58 | 4.58 |
| 538.69 | 4.44 | 4.44 |
| 524.66 | 4.19 | 4.19 |
| 536.67 | 4.34 | 4.34 |
| 552.67 | 3.57 | 3.57 |