ID: ALA144545

Max Phase: Preclinical

Molecular Formula: C25H23N7O10S2

Molecular Weight: 645.63

Molecule Type: Small molecule

Representations

Canonical SMILES:  O=c1c2nc(N(S(=O)(=O)c3ccc([N+](=O)[O-])cc3)S(=O)(=O)c3ccc([N+](=O)[O-])cc3)[nH]c2n(CC2CC2)c(=O)n1CC1CC1

Standard InChI:  InChI=1S/C25H23N7O10S2/c33-23-21-22(28(13-15-1-2-15)25(34)29(23)14-16-3-4-16)27-24(26-21)32(43(39,40)19-9-5-17(6-10-19)30(35)36)44(41,42)20-11-7-18(8-12-20)31(37)38/h5-12,15-16H,1-4,13-14H2,(H,26,27)

Standard InChI Key:  CUTNSPCPJMHGQC-UHFFFAOYSA-N

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Properties

Molecular Weight: 645.63

Molecular Weight (Monoisotopic): 645.0948

AlogP: 2.11

#Rotatable Bonds: 11

Polar Surface Area: 230.48

Molecular Species: NEUTRAL

HBA: 13

HBD: 1

#RO5 Violations: 2

HBA (Lipinski): 17

HBD (Lipinski): 1

#RO5 Violations (Lipinski): 2

CX Acidic pKa: 8.92

CX Basic pKa:

CX LogP: 3.40

CX LogD: 3.39

Aromatic Rings: 4

Heavy Atoms: 44

QED Weighted: 0.18

Np Likeness Score: -0.87

References

1. Buckle DR, Arch JR, Connolly BJ, Fenwick AE, Foster KA, Murray KJ, Readshaw SA, Smallridge M, Smith DG..  (1994)  Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine.,  37  (4): [PMID:8120866] [10.1021/jm00030a007]

Source

Source(1):

• Scientific Literature