| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ID: ALA1823903
Max Phase: Preclinical
Molecular Formula: C24H21Cl2NO3S
Molecular Weight: 474.41
Molecule Type: Small molecule
Associated Items:
Representations
Canonical SMILES: CC1(C)C=Cc2cc(CN(c3ccccc3)S(=O)(=O)c3cc(Cl)ccc3Cl)ccc2O1
Standard InChI: InChI=1S/C24H21Cl2NO3S/c1-24(2)13-12-18-14-17(8-11-22(18)30-24)16-27(20-6-4-3-5-7-20)31(28,29)23-15-19(25)9-10-21(23)26/h3-15H,16H2,1-2H3
Standard InChI Key: BZGNCAPNVBFAKW-UHFFFAOYSA-N
Associated Targets(Human)
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha 820 Activities
Molecule Features
| Natural Product: No | Oral: No | Chemical Probe: No | Parenteral: No |
| Molecule Type: Small molecule | Topical: No | First In Class: No | Black Box: No |
| Chirality: No | Availability: No | Prodrug: No |
Drug Indications
| MESH ID | MESH Heading | EFO IDs | EFO Terms | Max Phase for Indication | References |
|---|
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Properties
| Molecular Weight: 474.41 | Molecular Weight (Monoisotopic): 473.0619 | AlogP: 6.57 | #Rotatable Bonds: 5 |
| Polar Surface Area: 46.61 | Molecular Species: NEUTRAL | HBA: 3 | HBD: 0 |
| #RO5 Violations: 1 | HBA (Lipinski): 4 | HBD (Lipinski): 0 | #RO5 Violations (Lipinski): 1 |
| CX Acidic pKa: | CX Basic pKa: | CX LogP: 6.52 | CX LogD: 6.52 |
| Aromatic Rings: 3 | Heavy Atoms: 31 | QED Weighted: 0.42 | Np Likeness Score: -0.59 |
References
| 1. Tan C, de Noronha RG, Devi NS, Jabbar AA, Kaluz S, Liu Y, Mooring SR, Nicolaou KC, Wang B, Van Meir EG.. (2011) Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors., 21 (18): [PMID:21831638] [10.1016/j.bmcl.2011.06.099] |
| 2. Mooring SR, Jin H, Devi NS, Jabbar AA, Kaluz S, Liu Y, Van Meir EG, Wang B.. (2011) Design and synthesis of novel small-molecule inhibitors of the hypoxia inducible factor pathway., 54 (24): [PMID:22032632] [10.1021/jm201018g] |
| 3. Mun J, Jabbar AA, Devi NS, Liu Y, Van Meir EG, Goodman MM.. (2012) Structure-activity relationship of 2,2-dimethyl-2H-chromene based arylsulfonamide analogs of 3,4-dimethoxy-N-[(2,2-dimethyl-2H-chromen-6-yl)methyl]-N-phenylbenzenesulfonamide, a novel small molecule hypoxia inducible factor-1 (HIF-1) pathway inhibitor and anti-cancer agent., 20 (14): [PMID:22682301] [10.1016/j.bmc.2012.04.064] |
Source
Source(1):