| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
PHOSPHINE
ID: ALA2227836
Max Phase: Preclinical
Molecular Formula: H3P
Molecular Weight: 34.00
Molecule Type: Small molecule
Associated Items:
Representations
Canonical SMILES: P
Standard InChI: InChI=1S/H3P/h1H3
Standard InChI Key: XYFCBTPGUUZFHI-UHFFFAOYSA-N
Associated Targets(non-human)
Tribolium confusum 93 Activities
Sitophilus oryzae 115 Activities
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Cryptolestes ferrugineus 76 Activities
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Sitophilus zeamais 188 Activities
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Molecule Features
| Natural Product: No | Oral: No | Chemical Probe: No | Parenteral: No |
| Molecule Type: Small molecule | Topical: No | First In Class: No | Black Box: No |
| Chirality: No | Availability: No | Prodrug: No |
Drug Indications
| MESH ID | MESH Heading | EFO IDs | EFO Terms | Max Phase for Indication | References |
|---|
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Properties
| Molecular Weight: 34.00 | Molecular Weight (Monoisotopic): 33.9972 | AlogP: 0.06 | #Rotatable Bonds: 0 |
| Polar Surface Area: 0.00 | Molecular Species: | HBA: 0 | HBD: 0 |
| #RO5 Violations: 0 | HBA (Lipinski): 0 | HBD (Lipinski): 0 | #RO5 Violations (Lipinski): 0 |
| CX Acidic pKa: | CX Basic pKa: | CX LogP: -0.68 | CX LogD: -0.68 |
| Aromatic Rings: 0 | Heavy Atoms: 1 | QED Weighted: 0.33 | Np Likeness Score: 0.00 |
References
| 1. Mansour EltayebE, Mi Fengyu, Zhang Guoan, Jiugao Xie, Wang Yongmo, Kargbo Abu.. (2012) Effect of allylisothiocyanate on Sitophilus oryzae, Tribolium confusum and Plodia interpunctella: Toxicity and effect on insect mitochondria, 33 [10.1016/j.cropro.2011.11.010] |
| 2. Chu SS, Feng Hu J, Liu ZL.. (2011) Composition of essential oil of Chinese Chenopodium ambrosioides and insecticidal activity against maize weevil, Sitophilus zeamais., 67 (6): [PMID:21360645] [10.1002/ps.2112] |
| 3. Nayak MK, Holloway JC, Emery RN, Pavic H, Bartlet J, Collins PJ.. (2013) Strong resistance to phosphine in the rusty grain beetle, Cryptolestes ferrugineus (Stephens) (Coleoptera: Laemophloeidae): its characterisation, a rapid assay for diagnosis and its distribution in Australia., 69 (1): [PMID:22807213] [10.1002/ps.3360] |
Source
Source(1):