1. Fiorini I, Nacci V, Ciani SM, Garofalo A, Campiani G, Savini L, Novellino E, Greco G, Bernasconi P, Mennini T.. (1994) Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies., 37 (10): [PMID:8182701] [10.1021/jm00036a007] |
2. Kupczyk-Subotkowska L, Siahaan TJ, Basile AS, Friedman HS, Higgins PE, Song D, Gallo JM.. (1997) Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate., 40 (11): [PMID:9171882] [10.1021/jm960592p] |
3. Primofiore G, Da Settimo F, Taliani S, Simorini F, Patrizi MP, Novellino E, Greco G, Abignente E, Costa B, Chelli B, Martini C.. (2004) N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor., 47 (7): [PMID:15027878] [10.1021/jm030973k] |
4. Van Dort ME, Ciliax BJ, Gildersleeve DL, Sherman PS, Rosenspire KC, Young AB, Junck L, Wieland DM.. (1988) Radioiodinated benzodiazepines: agents for mapping glial tumors., 31 (11): [PMID:2846836] [10.1021/jm00119a005] |
5. TenBrink RE, Bergh CL, Duncan JN, Harris DW, Huff RM, Lahti RA, Lawson CF, Lutzke BS, Martin IJ, Rees SA, Schlachter SK, Sih JC, Smith MW.. (1996) (S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist., 39 (13): [PMID:8691438] [10.1021/jm960084f] |
6. Boitano A, Emal CD, Leonetti F, Blatt NB, Dineen TA, Ellman JA, Roush WR, Opipari AW, Glick GD.. (2003) Structure activity studies of a novel cytotoxic benzodiazepine., 13 (19): [PMID:12951119] [10.1016/s0960-894x(03)00683-8] |
7. Campiani G, Nacci V, Fiorini I, De Filippis MP, Garofalo A, Ciani SM, Greco G, Novellino E, Williams DC, Zisterer DM, Woods MJ, Mihai C, Manzoni C, Mennini T.. (1996) Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands., 39 (18): [PMID:8784441] [10.1021/jm960251b] |
8. Dalpiaz A, Bertolasi V, Borea PA, Nacci V, Fiorini I, Campiani G, Mennini T, Manzoni C, Novellino E, Greco G.. (1995) A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors., 38 (23): [PMID:7473601] [10.1021/jm00023a013] |
9. Mohler ML, Kang GS, Hong SS, Patil R, Kirichenko OV, Li W, Rakov IM, Geisert EE, Miller DD.. (2006) Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues., 49 (19): [PMID:16970409] [10.1021/jm060020x] |
10. Taliani S, Simorini F, Sergianni V, La Motta C, Da Settimo F, Cosimelli B, Abignente E, Greco G, Novellino E, Rossi L, Gremigni V, Spinetti F, Chelli B, Martini C.. (2007) New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation., 50 (2): [PMID:17228885] [10.1021/jm061137o] |
11. Dourlat J, Liu WQ, Gresh N, Garbay C.. (2007) Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines., 17 (9): [PMID:17317183] [10.1016/j.bmcl.2007.02.016] |
12. Cleary J, Johnson KM, Opipari AW, Glick GD.. (2007) Inhibition of the mitochondrial F1F0-ATPase by ligands of the peripheral benzodiazepine receptor., 17 (6): [PMID:17251020] [10.1016/j.bmcl.2006.12.102] |
13. Da Settimo F, Simorini F, Taliani S, La Motta C, Marini AM, Salerno S, Bellandi M, Novellino E, Greco G, Cosimelli B, Da Pozzo E, Costa B, Simola N, Morelli M, Martini C.. (2008) Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis., 51 (18): [PMID:18729350] [10.1021/jm8003224] |
14. Scarf AM, Ittner LM, Kassiou M.. (2009) The translocator protein (18 kDa): central nervous system disease and drug design., 52 (3): [PMID:19133775] [10.1021/jm8011678] |
15. Yu W, Wang E, Voll RJ, Miller AH, Goodman MM.. (2008) Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor., 16 (11): [PMID:18472268] [10.1016/j.bmc.2008.04.046] |
16. Taliani S, Da Pozzo E, Bellandi M, Bendinelli S, Pugliesi I, Simorini F, La Motta C, Salerno S, Marini AM, Da Settimo F, Cosimelli B, Greco G, Novellino E, Martini C.. (2010) Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization., 53 (10): [PMID:20438080] [10.1021/jm100100q] |
17. PubChem BioAssay data set, |
18. Pike VW, Taliani S, Lohith TG, Owen DR, Pugliesi I, Da Pozzo E, Hong J, Zoghbi SS, Gunn RN, Parker CA, Rabiner EA, Fujita M, Innis RB, Martini C, Da Settimo F.. (2011) Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands., 54 (1): [PMID:21133364] [10.1021/jm101230g] |
19. Cosimelli B, Simorini F, Taliani S, La Motta C, Da Settimo F, Severi E, Greco G, Novellino E, Costa B, Da Pozzo E, Bendinelli S, Martini C.. (2011) Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein., 46 (9): [PMID:21824692] [10.1016/j.ejmech.2011.07.025] |
20. PubChem BioAssay data set, |
21. Castellano S, Taliani S, Milite C, Pugliesi I, Da Pozzo E, Rizzetto E, Bendinelli S, Costa B, Cosconati S, Greco G, Novellino E, Sbardella G, Stefancich G, Martini C, Da Settimo F.. (2012) Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein., 55 (9): [PMID:22489952] [10.1021/jm201703k] |
22. Fukaya T, Kodo T, Ishiyama T, Kakuyama H, Nishikawa H, Baba S, Masumoto S.. (2012) Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands., 20 (18): [PMID:22884355] [10.1016/j.bmc.2012.07.023] |
23. Castellano S, Taliani S, Viviano M, Milite C, Da Pozzo E, Costa B, Barresi E, Bruno A, Cosconati S, Marinelli L, Greco G, Novellino E, Sbardella G, Da Settimo F, Martini C.. (2014) Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors., 57 (6): [PMID:24580635] [10.1021/jm401721h] |
24. Blair T, Webb GA.. (1977) Electronic factors in the structure-activity relationship of some 1,4-benzodiazepin-2-ones., 20 (9): [PMID:926122] [10.1021/jm00219a019] |
25. Barresi E, Bruno A, Taliani S, Cosconati S, Da Pozzo E, Salerno S, Simorini F, Daniele S, Giacomelli C, Marini AM, La Motta C, Marinelli L, Cosimelli B, Novellino E, Greco G, Da Settimo F, Martini C.. (2015) Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides., 58 (15): [PMID:26177193] [10.1021/acs.jmedchem.5b00689] |
26. Kim T, Son WS, Morshed MN, Londhe AM, Jung SY, Park JH, Park WK, Lim SM, Park KD, Cho SJ, Jeong KS, Lee J, Pae AN.. (2017) Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity., 141 [PMID:29031071] [10.1016/j.ejmech.2017.09.033] |
27. Robello M, Barresi E, Baglini E, Salerno S, Taliani S, Settimo FD.. (2021) The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities., 64 (7.0): [PMID:33764065] [10.1021/acs.jmedchem.0c01808] |
28. Giordani A, Menziani MC, Moresco RM, Matarrese M, Paolino M, Saletti M, Giuliani G, Anzini M, Cappelli A.. (2021) Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria., 64 (14.0): [PMID:34254805] [10.1021/acs.jmedchem.1c00379] |