ID: ALA3234455

Max Phase: Preclinical

Molecular Formula: C40H52F9N9O10S

Molecular Weight: 680.90

Molecule Type: Small molecule

Representations

Canonical SMILES:  CC(=O)NCCCC[C@H](NC(=O)Cc1csc(=N)n1C)C(=O)N[C@@H](Cc1cn(Cc2ccccc2)c[n+]1C)C(=O)NC1CCN(C)CC1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C([O-])C(F)(F)F

Standard InChI:  InChI=1S/C34H49N9O4S.3C2HF3O2/c1-24(44)36-15-9-8-12-29(38-31(45)19-28-22-48-34(35)42(28)4)32(46)39-30(33(47)37-26-13-16-40(2)17-14-26)18-27-21-43(23-41(27)3)20-25-10-6-5-7-11-25;3*3-2(4,5)1(6)7/h5-7,10-11,21-23,26,29-30,35H,8-9,12-20H2,1-4H3,(H3-,36,37,38,39,44,45,46,47);3*(H,6,7)/t29-,30-;;;/m0.../s1

Standard InChI Key:  UOWYNKTUMKVAFW-BPTUYQQTSA-N

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Small molecule

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Properties

Molecular Weight: 680.90

Molecular Weight (Monoisotopic): 680.3701

AlogP: 0.51

#Rotatable Bonds: 16

Polar Surface Area: 157.23

Molecular Species: BASE

HBA: 9

HBD: 5

#RO5 Violations: 1

HBA (Lipinski): 13

HBD (Lipinski): 5

#RO5 Violations (Lipinski): 2

CX Acidic pKa: 12.02

CX Basic pKa: 10.58

CX LogP: -4.30

CX LogD: -7.68

Aromatic Rings: 3

Heavy Atoms: 48

QED Weighted: 0.11

Np Likeness Score: -0.53

References

1. Margathe JF, Iturrioz X, Alvear-Perez R, Marsol C, Riché S, Chabane H, Tounsi N, Kuhry M, Heissler D, Hibert M, Llorens-Cortes C, Bonnet D..  (2014)  Structure-activity relationship studies toward the discovery of selective apelin receptor agonists.,  57  (7): [PMID:24625069] [10.1021/jm401789v]

Source

Source(1):

• Scientific Literature