| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
ID: ALA3694414
Max Phase: Preclinical
Molecular Formula: C19H16BF3N2O5
Molecular Weight: 420.15
Molecule Type: Small molecule
Associated Items:
Representations
Canonical SMILES: CC(=O)CCCOc1nc(Oc2ccc3c(c2)COB3O)cc(C(F)(F)F)c1C#N
Standard InChI: InChI=1S/C19H16BF3N2O5/c1-11(26)3-2-6-28-18-14(9-24)15(19(21,22)23)8-17(25-18)30-13-4-5-16-12(7-13)10-29-20(16)27/h4-5,7-8,27H,2-3,6,10H2,1H3
Standard InChI Key: NSVZCMUAFBWPEB-UHFFFAOYSA-N
Associated Targets(Human)
Phosphodiesterase 4A 1943 Activities
Phosphodiesterase 4B 2748 Activities
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Molecule Features
| Natural Product: No | Oral: No | Chemical Probe: No | Parenteral: No |
| Molecule Type: Small molecule | Topical: No | First In Class: No | Black Box: No |
| Chirality: No | Availability: No | Prodrug: No |
Drug Indications
| MESH ID | MESH Heading | EFO IDs | EFO Terms | Max Phase for Indication | References |
|---|
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Properties
| Molecular Weight: 420.15 | Molecular Weight (Monoisotopic): 420.1104 | AlogP: | #Rotatable Bonds: |
| Polar Surface Area: | Molecular Species: | HBA: | HBD: |
| #RO5 Violations: | HBA (Lipinski): | HBD (Lipinski): | #RO5 Violations (Lipinski): |
| CX Acidic pKa: | CX Basic pKa: | CX LogP: | CX LogD: |
| Aromatic Rings: | Heavy Atoms: | QED Weighted: | Np Likeness Score: |
References
| 1. (2014) Boron-containing small molecules, |
| 2. (2016) Boron containing small molecules, |
Source
Source(1):