| 1. Prinz H, Ishii Y, Hirano T, Stoiber T, Camacho Gomez JA, Schmidt P, Düssmann H, Burger AM, Prehn JH, Günther EG, Unger E, Umezawa K.. (2003) Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization., 46 (15): [PMID:12852768] [10.1021/jm0307685] |
| 2. Brady SF, Pawluczyk JM, Lumma PK, Feng DM, Wai JM, Jones R, DeFeo-Jones D, Wong BK, Miller-Stein C, Lin JH, Oliff A, Freidinger RM, Garsky VM.. (2002) Design and synthesis of a pro-drug of vinblastine targeted at treatment of prostate cancer with enhanced efficacy and reduced systemic toxicity., 45 (21): [PMID:12361397] [10.1021/jm020139f] |
| 3. Morrell A, Jayaraman M, Nagarajan M, Fox BM, Meckley MR, Ioanoviciu A, Pommier Y, Antony S, Hollingshead M, Cushman M.. (2006) Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay., 16 (16): [PMID:16750365] [10.1016/j.bmcl.2006.05.048] |
| 4. Zuse A, Schmidt P, Baasner S, Böhm KJ, Müller K, Gerlach M, Günther EG, Unger E, Prinz H.. (2006) 9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization., 49 (26): [PMID:17181164] [10.1021/jm0605031] |
| 5. Zuse A, Schmidt P, Baasner S, Böhm KJ, Müller K, Gerlach M, Günther EG, Unger E, Prinz H.. (2007) Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization., 50 (24): [PMID:17973361] [10.1021/jm0708984] |
| 6. Williams NS, Burgett AW, Atkins AS, Wang X, Harran PG, McKnight SL.. (2007) Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity., 104 (7): [PMID:17287337] [10.1073/pnas.0611340104] |
| 7. Ahsan M, Islam SK, Gray AI, Stimson WH.. (2003) Cytotoxic diterpenes from Scoparia dulcis., 66 (7): [PMID:12880314] [10.1021/np020356j] |
| 8. Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Unger E, Gerlach M, Günther EG.. (2009) 10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization., 52 (5): [PMID:19220018] [10.1021/jm801338r] |
| 9. Wu TS, Liou MJ, Kuoh CS, Teng CM, Nagao T, Lee KH.. (1997) Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia., 60 (6): [PMID:9214732] [10.1021/np970163+] |
| 10. Fortin JS, Côté MF, Lacroix J, Desjardins M, Petitclerc E, C-Gaudreault R.. (2008) Selective alkylation of beta(II)-tubulin and thioredoxin-1 by structurally related subsets of aryl chloroethylureas leading to either anti-microtubules or redox modulating agents., 16 (15): [PMID:18617414] [10.1016/j.bmc.2008.06.028] |
| 11. Tundis R, Bonesi M, Deguin B, Loizzo MR, Menichini F, Conforti F, Tillequin F, Menichini F.. (2009) Cytotoxic activity and inhibitory effect on nitric oxide production of triterpene saponins from the roots of Physospermum verticillatum (Waldst & Kit) (Apiaceae)., 17 (13): [PMID:19467877] [10.1016/j.bmc.2009.05.006] |
| 12. Nickel HC, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Unger E, Günther EG, Prinz H.. (2010) Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety., 45 (8): [PMID:20537765] [10.1016/j.ejmech.2010.04.032] |
| 13. Surkau G, Böhm KJ, Müller K, Prinz H.. (2010) Synthesis, antiproliferative activity and inhibition of tubulin polymerization by anthracenone-based oxime derivatives., 45 (8): [PMID:20546980] [10.1016/j.ejmech.2010.04.019] |
| 14. Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ.. (2009) Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum., 5 (10): [PMID:19734910] [10.1038/nchembio.215] |
| 15. Diamandis P, Wildenhain J, Clarke ID, Sacher AG, Graham J, Bellows DS, Ling EK, Ward RJ, Jamieson LG, Tyers M, Dirks PB.. (2007) Chemical genetics reveals a complex functional ground state of neural stem cells., 3 (5): [PMID:17417631] [10.1038/nchembio873] |
| 16. PubChem BioAssay data set, |
| 17. PubChem BioAssay data set, |
| 18. Greene N, Fisk L, Naven RT, Note RR, Patel ML, Pelletier DJ.. (2010) Developing structure-activity relationships for the prediction of hepatotoxicity., 23 (7): [PMID:20553011] [10.1021/tx1000865] |
| 19. Ekins S, Williams AJ, Xu JJ.. (2010) A predictive ligand-based Bayesian model for human drug-induced liver injury., 38 (12): [PMID:20843939] [10.1124/dmd.110.035113] |
| 20. Unpublished dataset, |
| 21. PubChem BioAssay data set, |
| 22. Prinz H, Chamasmani B, Vogel K, Böhm KJ, Aicher B, Gerlach M, Günther EG, Amon P, Ivanov I, Müller K.. (2011) N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization., 54 (12): [PMID:21563750] [10.1021/jm200436t] |
| 23. Prinz H, Schmidt P, Böhm KJ, Baasner S, Müller K, Gerlach M, Günther EG, Unger E.. (2011) Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization., 19 (14): [PMID:21705223] [10.1016/j.bmc.2011.06.010] |
| 24. Krishnegowda G, Prakasha Gowda AS, Tagaram HR, Carroll KF, Irby RB, Sharma AK, Amin S.. (2011) Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway., 19 (20): [PMID:21920762] [10.1016/j.bmc.2011.08.044] |
| 25. Liu Z, Shi Q, Ding D, Kelly R, Fang H, Tong W.. (2011) Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps)., 7 (12): [PMID:22194678] [10.1371/journal.pcbi.1002310] |
| 26. Sivasothy Y, Hadi AH, Mohamad K, Leong KH, Ibrahim H, Sulaiman SF, Ooi KL, Awang K.. (2012) Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff., 22 (11): [PMID:22546674] [10.1016/j.bmcl.2012.02.064] |
| 27. USP Dictionary of USAN and International Names (2010 edition) and USAN registrations 2007-date, |
| 28. Brunhofer G, Fallarero A, Karlsson D, Batista-Gonzalez A, Shinde P, Gopi Mohan C, Vuorela P.. (2012) Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine., 20 (22): [PMID:23062825] [10.1016/j.bmc.2012.09.040] |
| 29. PubChem BioAssay data set, |
| 30. PubChem BioAssay data set, |
| 31. Altshuler O, Abu-Abied M, Chaimovitsh D, Shechter A, Frucht H, Dudai N, Sadot E.. (2013) Enantioselective effects of (+)- and (-)-citronellal on animal and plant microtubules., 76 (9): [PMID:23947826] [10.1021/np4002702] |
| 32. Zheng J, Deng L, Chen M, Xiao X, Xiao S, Guo C, Xiao G, Bai L, Ye W, Zhang D, Chen H.. (2013) Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., 65 [PMID:23708010] [10.1016/j.ejmech.2013.04.057] |
| 33. PubChem BioAssay data set, |
| 34. PubChem BioAssay data set, |
| 35. Conrad RA, Cullinan GJ, Gerzon K, Poore GA.. (1979) Structure-activity relationships of dimeric Catharanthus alkaloids. 2. Experimental antitumor activities of N-substituted deacetylvinblastine amide (vindesine) sulfates., 22 (4): [PMID:430477] [10.1021/jm00190a008] |
| 36. Barnett CJ, Cullinan GJ, Gerzon K, Hoying RC, Jones WE, Newlon WM, Poore GA, Robison RL, Sweeney MJ, Todd GC, Dyke RW, Nelson RL.. (1978) Structure-activity relationships of dimeric Catharanthus alkaloids. 1. Deacetylvinblastine amide (vindesine) sulfate., 21 (1): [PMID:412968] [10.1021/jm00199a016] |
| 37. British National Formulary (72nd edition), |
| 38. Unpublished dataset, |
| 39. Bernhard Ellinger, Denisa Bojkova, Andrea Zaliani, Jindrich Cinatl, Carsten Claussen, Sandra Westhaus, Jeanette Reinshagen, Maria Kuzikov, Markus Wolf, Gerd Geisslinger, Philip Gribbon, Sandra Ciesek. (2020) Identification of inhibitors of SARS-CoV-2 in-vitro cellular toxicity in human (Caco-2) cells using a large scale drug repurposing collection, [10.21203/rs.3.rs-23951/v1] |
| 40. Maria Kuzikov, Elisa Costanzi, Jeanette Reinshagen, Francesca Esposito, Laura Vangeel, Markus Wolf, Bernhard Ellinger, Carsten Claussen, Gerd Geisslinger, Angela Corona, Daniela Iaconis, Carmine Talarico, Candida Manelfi, Rolando Cannalire, Giulia Rossetti, Jonas Gossen, Simone Albani, Francesco Musiani, Katja Herzog, Yang Ye, Barbara Giabbai, Nicola Demitri, Dirk Jochmans, Steven De Jonghe, Jasper Rymenants, Vincenzo Summa, Enzo Tramontano, Andrea R. Beccari, Pieter Leyssen, Paola Storici, Johan Neyts, Philip Gribbon, and Andrea Zaliani. (2020) Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen, [10.6019/CHEMBL4495564] |
| 41. Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen. (2020) Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort, [10.6019/CHEMBL4495565] |
| 42. Bernhard Ellinger, Justus Dick, Vanessa Lage-Rupprecht, Bruce Schultz, Andrea Zaliani, Marcin Namysl, Stephan Gebel, Ole Pless, Jeanette Reinshagen, Christian Ebeling, Alexander Esser, Marc Jacobs, Carsten Claussen, and Martin Hofmann-Apitius. (2021) HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators, [10.6019/CHEMBL4808148] |
| 43. Institute for Molecular Medicine Finland - High Throughput Biomedicine Unit. (2023) ECBD screening data for assay EOS300108, [10.6019/EOS300108] |
