| 1. Zheng W, Padia J, Urban DJ, Jadhav A, Goker-Alpan O, Simeonov A, Goldin E, Auld D, LaMarca ME, Inglese J, Austin CP, Sidransky E.. (2007) Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease., 104 (32): [PMID:17670938] [10.1073/pnas.0705637104] |
| 2. Wang GN, Reinkensmeier G, Zhang SW, Zhou J, Zhang LR, Zhang LH, Butters TD, Ye XS.. (2009) Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease., 52 (10): [PMID:19397268] [10.1021/jm801506m] |
| 3. Díaz L, Bujons J, Casas J, Llebaria A, Delgado A.. (2010) Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease., 53 (14): [PMID:20557054] [10.1021/jm100198t] |
| 4. PubChem BioAssay data set, |
| 5. Ghisaidoobe A, Bikker P, de Bruijn AC, Godschalk FD, Rogaar E, Guijt MC, Hagens P, Halma JM, Van't Hart SM, Luitjens SB, van Rixel VH, Wijzenbroek M, Zweegers T, Donker-Koopman WE, Strijland A, Boot R, van der Marel G, Overkleeft HS, Aerts JM, van den Berg RJ.. (2011) Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars., 2 (2): [PMID:24900289] [10.1021/ml100192b] |
| 6. Chang J, Wang L, Ma D, Qu X, Guo H, Xu X, Mason PM, Bourne N, Moriarty R, Gu B, Guo JT, Block TM.. (2009) Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses., 53 (4): [PMID:19223639] [10.1128/aac.01457-08] |
| 7. Rasmussen TS, Allman S, Twigg G, Butters TD, Jensen HH.. (2011) Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease., 21 (5): [PMID:21292481] [10.1016/j.bmcl.2010.12.106] |
| 8. Díaz L, Casas J, Bujons J, Llebaria A, Delgado A.. (2011) New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening., 54 (7): [PMID:21370884] [10.1021/jm101204u] |
| 9. Trapero A, Llebaria A.. (2011) The myo-1,2-Diaminocyclitol Scaffold Defines Potent Glucocerebrosidase Activators and Promising Pharmacological Chaperones for Gaucher Disease., 2 (8): [PMID:24900357] [10.1021/ml200098j] |
| 10. Yu W, Gill T, Wang L, Du Y, Ye H, Qu X, Guo JT, Cuconati A, Zhao K, Block TM, Xu X, Chang J.. (2012) Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection., 55 (13): [PMID:22712544] [10.1021/jm300171v] |
| 11. Castilla J, Rísquez R, Cruz D, Higaki K, Nanba E, Ohno K, Suzuki Y, Díaz Y, Ortiz Mellet C, García Fernández JM, Castillón S.. (2012) Conformationally-locked N-glycosides with selective β-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease., 55 (15): [PMID:22762530] [10.1021/jm3006178] |
| 12. Trapero A, González-Bulnes P, Butters TD, Llebaria A.. (2012) Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease., 55 (9): [PMID:22512696] [10.1021/jm300342q] |
| 13. Liu J, Obando D, Liao V, Lifa T, Codd R.. (2011) The many faces of the adamantyl group in drug design., 46 (6): [PMID:21354674] [10.1016/j.ejmech.2011.01.047] |
| 14. Boyd RE, Lee G, Rybczynski P, Benjamin ER, Khanna R, Wustman BA, Valenzano KJ.. (2013) Pharmacological chaperones as therapeutics for lysosomal storage diseases., 56 (7): [PMID:23363020] [10.1021/jm301557k] |
| 15. Cheng WC, Weng CY, Yun WY, Chang SY, Lin YC, Tsai FJ, Huang FY, Chen YR.. (2013) Rapid modifications of N-substitution in iminosugars: development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease., 21 (17): [PMID:23880081] [10.1016/j.bmc.2013.06.054] |
| 16. Tedaldi L, Wagner GK. (2014) Beyond substrate analogues: new inhibitor chemotypes for glycosyltransferases, 5 (8): [10.1039/C4MD00086B] |
| 17. Wang J, Wang X, Zhao Y, Ma X, Wan Y, Chen Z, Chen H, Gan H, Li J, Li L, Wang PG, Zhao W. (2016) Synthesis and biological evaluation ofd-gluconhydroximo-1,5-lactam and its oxime-substituted derivatives as pharmacological chaperones for the treatment of Gaucher disease, 7 (2): [10.1039/C5MD00501A] |
| 18. García-Moreno MI, de la Mata M, Sánchez-Fernández EM, Benito JM, Díaz-Quintana A, Fustero S, Nanba E, Higaki K, Sánchez-Alcázar JA, García Fernández JM, Ortiz Mellet C.. (2017) Fluorinated Chaperone-β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease., 60 (5): [PMID:28171725] [10.1021/acs.jmedchem.6b01550] |
| 19. Ma J, Wu S, Zhang X, Guo F, Yang K, Guo J, Su Q, Lu H, Lam P, Li Y, Yan Z, Kinney W, Guo JT, Block TM, Chang J, Du Y.. (2017) Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction., 8 (2): [PMID:28197304] [10.1021/acsmedchemlett.6b00332] |
| 20. Sevšek A, Sastre Toraño J, Quarles van Ufford L, Moret EE, Pieters RJ, Martin NI.. (2017) Orthoester functionalized N-guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase., 8 (11): [PMID:30108721] [10.1039/C7MD00480J] |
| 21. De Fenza M, D'Alonzo D, Esposito A, Munari S, Loberto N, Santangelo A, Lampronti I, Tamanini A, Rossi A, Ranucci S, De Fino I, Bragonzi A, Aureli M, Bassi R, Tironi M, Lippi G, Gambari R, Cabrini G, Palumbo G, Dechecchi MC, Guaragna A.. (2019) Exploring the effect of chirality on the therapeutic potential of N-alkyl-deoxyiminosugars: anti-inflammatory response to Pseudomonas aeruginosa infections for application in CF lung disease., 175 [PMID:31075609] [10.1016/j.ejmech.2019.04.061] |
| 22. Behnam MA, Nitsche C, Boldescu V, Klein CD.. (2016) The Medicinal Chemistry of Dengue Virus., 59 (12): [PMID:26771861] [10.1021/acs.jmedchem.5b01653] |
