ID: ALA4635521

Max Phase: Preclinical

Molecular Formula: C38H46Br2N10O5

Molecular Weight: 882.66

Molecule Type: Unknown

Representations

Canonical SMILES:  O=C(N[C@@H](CC1CCNCC1)C(=O)N1CCN(c2ccncc2)CC1)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1

Standard InChI:  InChI=1S/C38H46Br2N10O5/c39-28-20-25(21-29(40)33(28)51)23-30(45-37(54)49-14-7-27(8-15-49)50-32-2-1-9-43-34(32)46-38(50)55)35(52)44-31(22-24-3-10-41-11-4-24)36(53)48-18-16-47(17-19-48)26-5-12-42-13-6-26/h1-2,5-6,9,12-13,20-21,24,27,30-31,41,51H,3-4,7-8,10-11,14-19,22-23H2,(H,44,52)(H,45,54)(H,43,46,55)/t30-,31+/m1/s1

Standard InChI Key:  VJFRMTZBLLJSOE-JSOSNVBQSA-N

Molecule Features

Natural Product: No

Oral: No

Chemical Probe: No

Parenteral: No

Molecule Type: Unknown

Topical: No

First In Class: No

Black Box: No

Chirality: No

Availability: No

Prodrug: No

Properties

Molecular Weight: 882.66

Molecular Weight (Monoisotopic): 880.2019

AlogP: 3.53

#Rotatable Bonds: 10

Polar Surface Area: 180.82

Molecular Species: BASE

HBA: 10

HBD: 5

#RO5 Violations: 1

HBA (Lipinski): 15

HBD (Lipinski): 5

#RO5 Violations (Lipinski): 2

CX Acidic pKa: 6.75

CX Basic pKa: 10.18

CX LogP: 1.15

CX LogD: 0.41

Aromatic Rings: 4

Heavy Atoms: 55

QED Weighted: 0.16

Np Likeness Score: -0.82

References

1. Bucknell SJ, Ator MA, Brown AJH, Brown J, Cansfield AD, Cansfield JE, Christopher JA, Congreve M, Cseke G, Deflorian F, Jones CR, Mason JS, O'Brien MA, Ott GR, Pickworth M, Southall SM..  (2020)  Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.,  63  (14): [PMID:32558564] [10.1021/acs.jmedchem.0c01003]

Source

Source(1):

• Scientific Literature