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ID: ALA1121424

Journal: J Med Chem

Title: Orally active cephalosporins and penicillins.

Authors: Böhme EH, Bambury RE, Baumann RJ, Erickson RC, Harrison BL, Hoffman PF, McCarty FJ, Schnettler RA, Vaal MJ, Wenstrup DL.

Abstract: A number of orally active cephalosporins and penicillins with interesting biological activity were synthesized. Two of these, 7-[[[3,4-(methylenedioxy)phenyl]glycyl]amino]deacetoxycephalosporanic acid and 7-[[2-(2,3-dihydro-5-benzofuranyl)glycyl]amino]deacetoxycephalosporanic acid were considerably more active than cephalexin both in vitro and in vivo against staphylococcal and streptococcal infections.

CiteXplore: 7381838

DOI: 10.1021/jm00178a011