Adrenergic receptor agonists. Benzofuranylethanolamines.
Basic Information
ID: ALA1121448
Journal: J Med Chem
Title: Adrenergic receptor agonists. Benzofuranylethanolamines.
Authors: Lövgren K, Hedberg A, Nilsson JL.
Abstract: Two hydroxy-substituted benzofuranylethanolamines (9 and 10), analogues of adrenoceptor-active aryloxypropanolamines, were prepared and their beta-adrenoceptor activity was examined. Compound 9 was found to be a beta 1-selective adrenergic agonist with high intrinsic activity. Due to the rigidity of the benzofuranyl moiety of 9, its functional groups cannot be brought into the same spatial positions as those of a phenylethanolamine-type agonist like isoprenaline. This could indicate that adrenergic agonists of the aryloxypropanolamine type and of the phenylethanolamine type are differently bound to the receptor when eliciting the effect.
CiteXplore: 6104731
DOI: 10.1021/jm00180a008
Patent ID: ┄