Document Report Card

Basic Information

ID: ALA1121479

Journal: J Med Chem

Title: Simple beta-lactam compounds derived from 6-aminopenicillanic acid.

Authors: Sheehan JC, Shibahara S, Chacko E.

Abstract: As part of a general program of structural modification in beta-lactam antibiotics, we have synthesized several simple penicillins from 6-aminopenicillanic acid where the C-3 carboxyl group has been replaced by a hydroxy or an acetoxy group and the C-6 side chain has been substituted by bromine or hydrogen. Some of the compounds exhibit mild activity against the Gram-positive strain Bacillus subtilis.

CiteXplore: 6249932

DOI: 10.1021/jm00181a020