Document Report Card

ID: ALA1121480

Journal: J Med Chem

Title: Conversion of ergolines to hexahydro- and octahydrobenzo[f]quinolines (depyrroloergolines).

Authors: Bach NJ, Kornfeld EC, Clemens JA, Smalstig EB.

Abstract: A general method has been developed for removal of the pyrrole ring from the ergolines. Oxidation of various ergolines at the 2,3 double bond gave formamido ketones 10, which afforded the amino ketones 11. These were deaminated to give the ketones 12, from which the carbonyl group was removed by reduction. The resulting depyrroloergolines (9) have, in contrast to the ergolines, little or no dopamine agonist activity in two tests.

CiteXplore: 7190615

DOI: 10.1021/jm00181a021