Studies of hypolipidemic agents. 1. Synthesis and hypolipidemic activities of alkoxycinnamic acid derivatives.
Basic Information
ID: ALA1121524
Journal: J Med Chem
Title: Studies of hypolipidemic agents. 1. Synthesis and hypolipidemic activities of alkoxycinnamic acid derivatives.
Authors: Watanabe T, Hayashi K, Yoshimatsu S, Sakai K, Takeyama S, Takashima K.
Abstract: More than 110 derivatives of alkoxycinnamic acids were synthesized and their hypolipidemic activities were evaluated in a screening system with rats. Cinnamic acids, alpha-methylcinnamic acids, and their various esters with a higher p-alkoxy substituent were found to possess hypolipidemic activities higher than or comparable to that of clofibrate. The proper length (C12--C16) and the para position of the alkoxy substituent seem to be essential for activity. Chloroethyl and methacryloxyethyl esters and monoglycerides of some of the active p-alkoxycinnamic acids were more active than the corresponding free acids.
CiteXplore: 7359513
DOI: 10.1021/jm00175a010
Patent ID: ┄