Document Report Card

ID: ALA1121537

Journal: J Med Chem

Title: Anticoccidial derivatives of 6-azauracil. 3. Synthesis, high activity, and short plasma half-life of 1-phenyl-6-azauracils containing sulfonamide substituents.

Authors: Miller MW, Mylari BL, Howes HL, Figdor SK, Lynch MJ, Lynch JE, Koch RC.

Abstract: A series of 1-phenyl-6-azauracils containing sulfonamide substituents was prepared. In contrast to previous 1-phenyl-6-azauracils, some of these sulfonamides combine high activity against Eimeria tenella infections in chickens with a very rapid rate of clearance from plasma. Most active was 1-[3'-chloro-5'-methyl-4'-(morpholinylsulfonyl)phenyl]-6-azauracil, with a minimum effective concentration in feed of about 10 ppm.

CiteXplore: 6893468

DOI: 10.1021/jm00184a005