Document Report Card

ID: ALA1121570

Journal: J Med Chem

Title: 3-(4-Piperidinylalkyl)indoles, selective inhibitors of neuronal 5-hydroxytryptamine uptake.

Authors: Gueremy C, Audiau F, Champseix, Uzan A, Le Fur G, Rataud J.

Abstract: A series of 3-(4-piperidinylalkyl)indoles was synthesized and tested as uptake inhibitors of biogenic amines. Some of these compounds are potent and very selective in blocking the 5-hydroxytryptamine (5-HT) uptake, as evidenced by biochemical data and behavioral tests. A discussion on structure-activity relationships is given. The most interesting member of the series, indalpine, 3-[2-(4-piperidinyl)ethyl]indole (1), was selected for clinical studies.

CiteXplore: 7452682

DOI: 10.1021/jm00186a005