Document Report Card

ID: ALA1121618

Journal: J Med Chem

Title: Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines.

Authors: Nakayama C, Wataya Y, Meyer RB, Santi DV, Saneyoshi M, Ueda T.

Abstract: A continuous spectrophotometric assay for thymidine phosphorylase has been developed and used to analyze the substrate properties of a number of 5-substituted 2'-deoxyuridines. A QSAR was found which relates the catalytic efficiency for various substrates to a single variable, the inductive field constant F.

CiteXplore: 7401121

DOI: 10.1021/jm00182a029