Document Report Card

ID: ALA1121636

Journal: J Med Chem

Title: 4a,9b-trans-8-Fluoro-5-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole hydrochloride, a new potent neuroleptic.

Authors: Welch WM, Ewing FE, Harbert CA, Weissman A, Koe BK.

Abstract: The preparation and testing of the two racemic diastereoisomers and the four optically active enantiomers of the title compound in in vitro and in vivo models for determining potential antipsychotic activity are described. Both racemic diastereoisomers and two of the four chiral enantiomers are potent and long-acting neuroleptic compounds.

CiteXplore: 6105220

DOI: 10.1021/jm00182a025