Document Report Card

ID: ALA1121696

Journal: J Med Chem

Title: Antimicrobial 3-methyleneflavanones.

Authors: Ward FE, Garling DL, Buckler RT, Lawler DM, Cummings DP.

Abstract: The antimicrobial activity previously attributed to flavanone Mannich bases was found to be due to their breakdown products, 3-methyleneflavanones. Among the latter compounds, highest potency was observed when the flavanone phenyl ring contained bromine or chlorine substituents. 3-Methylene-2-phenylflavanone (8) was synthesized and shown to be equal to hexachlorophene in tests against representative Gram-positive microorganisms.

CiteXplore: 7288822

DOI: 10.1021/jm00141a011