Document Report Card

ID: ALA1121729

Journal: J Med Chem

Title: N*-N*-S* tridentate ligand system as potential antitumor agents.

Authors: Antonini I, Claudi F, Cristalli G, Franchetti P, Grifantini M, Martelli S.

Abstract: Compounds containing an N*-N*-S* tridentate ligand were synthesized and tested for antitumor activity against P-388 lymphocytic leukemia in mice. Of these, only 2,2'-bipyridyl-6-carbothioamide (1a) showed antitumor activity at relatively high dosage levels. Compound 1a was also evaluated against L-1210 and S180 cells in culture and found to have significant activity.

CiteXplore: 7328579

DOI: 10.1021/jm00142a012