Piperazinylquinoxalines with central serotoninmimetic activity.

ID: ALA1121884

Journal: J Med Chem

Title: Piperazinylquinoxalines with central serotoninmimetic activity.

Authors: Lumma WC, Hartman RD, Saari WS, Engelhardt EL, Lotti VJ, Stone CA.

Abstract: Regioselective syntheses of substituted 2-chloroquinoxalines and derived 2-(1-piperazinyl)quinoxalines are described. Selectivity in regards to serotonin reuptake blocking and serotoninmimetic activities of the piperazinylquinoxalines is reported. In general, introduction of a 6-substituent into the piperazinylquinoxaline enhanced serotonin reuptake blocking activity and diminished serotoninmimetic activity. Unsubstituted and 3-hydroxypiperazinylquinoxalines had primarily serotoninmimetic activity.

CiteXplore: 6451700

DOI: 10.1021/jm00133a019

Patent ID: ┄