Document Report Card

ID: ALA1121890

Journal: J Med Chem

Title: Synthesis and antimetastatic properties of steroeoisomeric trycylic bis(dioxopiperazine) analogues in a B16 melanoma model.

Authors: Witiak DT, Trivedi BK, Campolito LB, Zwilling BS, Reiches NA.

Abstract: The synthesis for trans and cis tricyclic bis(dioxopiperazine)s 5 and 6 from pyrazine-2,3-dicarboxamide (7) is described. Stereoselective antimetastatic activity differences for these analogues were observed following pretreatment of B16-F10 melanoma cells in vitro. Activities for these isomers were compared with selected intermediates, and the data are discussed in relation to previous results obtained with cis- and trans-cyclopropane analogues.

CiteXplore: 7310809

DOI: 10.1021/jm00143a013