Document Report Card

ID: ALA1121978

Journal: J Med Chem

Title: Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.

Authors: Erhardt PW, Woo CM, Anderson WG, Gorczynski RJ.

Abstract: Several short-acting beta-adrenergic receptor blocking agents have been prepared by incorporating ester functions into the aryl portion of certain (aryloxy)propanolamine systems. In particular, methyl 3-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]propionate hydrochloride (ASL-8052) was found to be a moderately potent, cardioselective compound with a short duration of action when determined in in vivo canine models.

CiteXplore: 6130154

DOI: 10.1021/jm00354a003