beta-adrenergic blocking agents. 24. Heterocyclic substituted 1-(aryloxy)-3-[[(amido)alkyl]amino]propan-2-ols.
Basic Information
ID: ALA1121980
Journal: J Med Chem
Title: beta-adrenergic blocking agents. 24. Heterocyclic substituted 1-(aryloxy)-3-[[(amido)alkyl]amino]propan-2-ols.
Authors: Large MS, Smith LH.
Abstract: The synthesis of a series of 1-(aryloxy)-3-[[(amido)alkyl]amino] propan-2-ols where either the aryl moiety is heterocyclic or the amidic group is substituted by a heterocyclic moiety is described. Several of the compounds were more potent than propranolol when given intravenously to anesthetized rats. In contrast to previous findings with beta-blockers based on heterocyclic moieties and with either an isopropylamino or tert-butylamino substituent on the side chain, several compounds proved to be cardioselective when further examined in anesthetized cats. The detailed structure-activity relationships shown by this series of compounds are discussed.
CiteXplore: 6130155
DOI: 10.1021/jm00354a005
Patent ID: ┄