Document Report Card

ID: ALA1122100

Journal: J Med Chem

Title: Pyridoquinoxaline N-oxides. 2. Synthesis and antibacterial activity of tricyclic lactams.

Authors: Glazer EA, Presslitz JE.

Abstract: A series of novel 3,4-dihydropyrido[3,4-b]quinoxalin-1(2H)-one 5,10-dioxides was synthesized using an intramolecular amidation reaction. The lactams were screened in vitro and in vivo against Salmonella choleraesuis, Pasteurella multocida, and Escherichia coli. An N-methyl analogue was the most potent member of this series, with antibacterial activity comparable to that of the commercially important quinoxaline 1,4-dioxide carbadox.

CiteXplore: 7108904

DOI: 10.1021/jm00349a021