Document Report Card

ID: ALA1122115

Journal: J Med Chem

Title: Antimalarials. 13. 5-Alkoxy analogues of 4-methylprimaquine.

Authors: LaMontagne MP, Markovac A, Khan MS.

Abstract: A series of nuclear and side-chain analogues of 4-methylprimaquine incorporating an alkoxy group in the 5-position of the quinoline nucleus has been prepared. The compounds were tested for suppressive antimalarial activity against Plasmodium berghei in mice and for radical curative antimalarial activity against Plasmodium cynomolgi in the rhesus monkey. Although the toxicity problems characteristic of the 8-aminoquinolines were not overcome, several of the compounds, surprisingly, were highly effective as both blood and tissue schizonticidal agents.

CiteXplore: 6750123

DOI: 10.1021/jm00350a016