Document Report Card

ID: ALA1122221

Journal: J Med Chem

Title: Antimycotic azoles. 6. Synthesis and antifungal properties of terconazole, a novel triazole ketal.

Authors: Heeres J, Hendrickx R, Van Cutsem J.

Abstract: The preparation and antifungal properties of cis-1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1, 3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine are reported. Terconazole has a high topical in vivo activity against vaginal candidosis in rats and against dermatophytosis in guinea pigs.

CiteXplore: 6834396

DOI: 10.1021/jm00358a032