Document Report Card

ID: ALA1122288

Journal: J Med Chem

Title: Relationship between metabolism and radioprotective activity of 2-phenylthiazolidine and its m-bromo derivative.

Authors: Fernandez JP, Robbe Y, Chapat JP, Chanal JL, Genin M, Sentenac-Roumanou H, Fatome M.

Abstract: Molecular biotransformation of 2-phenylthiazolidine (1) and its m-bromo derivative (2) in the mouse is followed by autoradiographic studies and assessed by analysis of urinary metabolites. Cysteamine (4) is one of the metabolites of compounds 1 and 2. Radioprotective activity and efficacy over a period of time of 1, 2, and 4 correlate closely with distribution and metabolism.

CiteXplore: 6887207

DOI: 10.1021/jm00363a018