Document Report Card

ID: ALA1122399

Journal: J Med Chem

Title: Synthesis and antibacterial activities of new (alpha-hydrazinobenzyl)cephalosporins.

Authors: Balsamo A, Macchia B, Macchia F, Rossello A, Giani R, Pifferi G, Pinza M, Broccali G.

Abstract: Some (alpha-hydrazinobenzyl)cephalosporins, I (R = Me, CH2OAc, Cl) and II (R = Me, CH2OAc), structurally related (formula; see text) to cephalexin, cephaloglycin, and cefaclor have been prepared and evaluated in vitro for their antimicrobial activity. The synthesis involves the condensation of the chloride hydrochloride III (R = H or Me) with the 7-aminocephem derivatives IV. The hydrazino compound I (R = Cl), an analogue of cefaclor, resulted in being the most active compound of the series.

CiteXplore: 6631918

DOI: 10.1021/jm00365a019