Document Report Card

ID: ALA1122688

Journal: J Med Chem

Title: Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones.

Authors: Heeres J, Backx LJ, Van Cutsem J.

Abstract: A series of novel triazol-3-ones have been synthesized, and their in vitro and in vivo antifungal properties are reported. Compound 68 (itraconazole), which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, has been selected for clinical evaluation.

CiteXplore: 6330360

DOI: 10.1021/jm00373a015