Document Report Card

ID: ALA1122779

Journal: J Med Chem

Title: Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues.

Authors: Walsh DA, Moran HW, Shamblee DA, Uwaydah IM, Welstead WJ, Sancilio LF, Dannenburg WN.

Abstract: A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 157 (4'-chloro), 158 (4'-bromo), and 182 (5-chloro, 4'-bromo) were more potent than indomethacin in these assays.

CiteXplore: 6436487

DOI: 10.1021/jm00377a001