Document Report Card

ID: ALA1122789

Journal: J Med Chem

Title: Synthesis and biological activity of structural analogues of the anticancer benzophenanthridine alkaloid nitidine chloride.

Authors: Cushman M, Mohan P, Smith EC.

Abstract: The indenoisoquinoline analogue 9 of nitidine (1) has been prepared and found to possess significant anticancer activity against L1210 lymphoid leukemia, P388 lymphocytic leukemia, and B16 melanocarcinoma. Analogue 14, which lacks the B ring of nitidine (1), has also been synthesized. Compound 14 retains the in vitro toxicity associated with nitidine (1) but is devoid of antileukemic activity. The structural factors that may contribute to the difference in biological activity between the two closely related analogues 9 and 14 are discussed.

CiteXplore: 6708057

DOI: 10.1021/jm00370a021