Document Report Card

ID: ALA1122797

Journal: J Med Chem

Title: Benzisoxazolones: antimicrobial and antileukemic activity.

Authors: Wierenga W, Evans BR, Zurenko GE.

Abstract: An unusual acid-mediated rearrangement of o-nitrostyrene oxide afforded 1-(hydroxymethyl)-2,1-benzisoxazol-3(1H)-one which exhibited broad-spectrum antimicrobial and cytotoxic activity. A number of analogues were prepared by employing a modified zinc-reduction procedure on o-nitrobenzoate. Several of these analogues exhibited interesting antipseudomonal activity in agar and broth but were ineffective in vivo.

CiteXplore: 6471074

DOI: 10.1021/jm00375a022