Document Report Card

ID: ALA1122902

Journal: J Med Chem

Title: Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.

Authors: Taylor EC, Harrington PJ, Fletcher SR, Beardsley GP, Moran RG.

Abstract: Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described. These compounds exhibit significant in vivo activity against L1210 leukemia that is comparable to that observed with methotrexate.

CiteXplore: 4009615

DOI: 10.1021/jm00145a012