Document Report Card

ID: ALA1123507

Journal: J Med Chem

Title: Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines.

Authors: Markley LD, Tong YC, Dulworth JK, Steward DL, Goralski CT, Johnston H, Wood SG, Vinogradoff AP, Bargar TM.

Abstract: Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Compound 8 and several analogues each given orally prior to and during infection protected mice against an otherwise lethal challenge with coxsackievirus A21.

CiteXplore: 3005578

DOI: 10.1021/jm00153a020