Document Report Card

ID: ALA1123543

Journal: J Med Chem

Title: 3,7-Diazabicyclane: a new narcotic analgesic.

Authors: Salva PS, Hite GJ, Heyman RA, Gianutsos G.

Abstract: The synthesis of a series of 9-phenyl-3,7-diazabicyclanes and 9-(m-hydroxyphenyl)-3,7-diazabicyclanes is described. Members of both series were tested for antinociception in rat tail withdrawal and mouse acetic acid writhing assays. Their affinities for opiate receptors in rat brain homogenate were also determined. The 9-phenyl compounds, 1a-c, were inactive. However, the 9-(m-hydroxyphenyl) analogues, 2a-c, were found to possess significant activity in the writhing assay, comparable to that of morphine. All activity was reversed by naloxone.

CiteXplore: 2876106

DOI: 10.1021/jm00160a054