Document Report Card

ID: ALA1123582

Journal: J Med Chem

Title: Substituted 2-(2-hydroxyphenyl)benzimidazoles as potential agents for the control of periodontal diseases.

Authors: Coburn RA, Clark MT, Evans RT, Genco RJ.

Abstract: A series of 16 substituted 2-(2-hydroxphenyl)benzimidazoles was synthesized and evaluated in vitro for antibacterial activity against bacteria associated with periodontal diseases. Several compounds demonstrated a high level of activity, in tube dilution assay, against Actinomycetes viscosus and Bacteriodes gingivalis. These results indicate that several of these compounds may serve as topical antibacterial agents for the control of acute marginal inflammatory gingivitis and periodontitis.

CiteXplore: 3806595

DOI: 10.1021/jm00384a035