Document Report Card

ID: ALA1123779

Journal: J Med Chem

Title: Modifications of primaquine as antimalarials. 4. 5-Alkoxy derivatives of primaquine.

Authors: Chen EH, Tanabe K, Saggiomo AJ, Nodiff EA.

Abstract: Thirty-two 5-alkoxyprimaquines have been synthesized and evaluated as blood schizonticides (Plasmodium berghei, mouse) and tissue schizonticides (Plasmodium cynomolgi, monkey). Several of these compounds were extremely active in both screens. Such a broad spectrum of antimalarial efficacy offers the possibility of a single drug that could cure the various relapsing and nonrelapsing malarias.

CiteXplore: 3599024

DOI: 10.1021/jm00390a012